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lysC aspartate kinase III [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948531, updated on 3-Dec-2024

Summary

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Official Symbol
lysC
Official Full Name
aspartate kinase III
Primary source
ECOCYC:EG10550
Locus tag
b4024
See related
ASAP:ABE-0013156
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
apk; ECK4016
Summary
Mutations in an L box riboswitch regulated by free lysine is in the lysC mRNA 5' UTR confer resistance to S-(2-aminoethyl)-L-cysteine (AEC) by derepressing lysine biosynthesis and outcompeting AEC inhibition of LysRS (Ataide, 2007). [More information is available at EcoGene: EG10550]. Aspartokinase III (LysC) is one of three aspartokinase activities catalyzing the first step in the biosynthesis of lysine and homoserine, and indirectly methionine and threonine. [More information is available at EcoCyc: EG10550].
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Genomic context

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Sequence:
NC_000913.3 (4231884..4233233, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 23S rRNA pseudouridine(2604) and tRNA(Tyr) pseudouridine(35) synthase Neighboring gene DUF3811 domain-containing protein YjbD Neighboring gene glucose-6-phosphate isomerase Neighboring gene uncharacterized protein YjbE

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nucleotide sequence of the promoter region of the E. coli lysC gene. Cassan M, et al. Nucleic Acids Res, 1983 Sep 24. PMID 6312411, Free PMC Article
  2. The leader sequence of the Escherichia coli lysC gene is involved in the regulation of LysC synthesis. Patte JC, et al. FEMS Microbiol Lett, 1998 Dec 1. PMID 9851048
  3. Mutational analysis of the feedback sites of lysine-sensitive aspartokinase of Escherichia coli. Kikuchi Y, et al. FEMS Microbiol Lett, 1999 Apr 1. PMID 10220897
  4. Effects of a feedback-resistant aspartokinase III gene on L-isoleucine production in Escherichia coli K-12. Hashiguchi K, et al. Biosci Biotechnol Biochem, 1999 Nov. PMID 10635571
  5. Analysis of the regulatory region of the lysC gene of Escherichia coli. Liao HH, et al. FEMS Microbiol Lett, 1998 Nov 1. PMID 9812360

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aspartate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aspartate kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aspartate kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in homoserine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within homoserine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lysine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lysine biosynthetic process via diaminopimelate IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lysine biosynthetic process via diaminopimelate IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
aspartate kinase III
NP_418448.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4231884..4233233 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418448.1 aspartate kinase III [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418448.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2H4TS34
    Conserved Domains (1) summary
    PRK09084
    Location:4 → 449
    PRK09084; aspartate kinase III; Validated
Nucleotide Protein
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