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iclR DNA-binding transcriptional repressor IclR [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948524, updated on 10-Oct-2024

Summary

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Official Symbol
iclR
Official Full Name
DNA-binding transcriptional repressor IclR
Primary source
ECOCYC:EG10491
Locus tag
b4018
See related
ASAP:ABE-0013136
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4010
Summary
Tetrameric IclR binds to the aceBA operator and dimeric IclR is inactive. [More information is available at EcoGene: EG10491]. IclR belongs to the IclR family. [More information is available at EcoCyc: EG10491].
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Genomic context

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Sequence:
NC_000913.3 (4222804..4223628, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene isocitrate dehydrogenase kinase/phosphatase Neighboring gene regulator of acetyl CoA synthetase Neighboring gene cobalamin-dependent methionine synthase Neighboring gene putative inorganic phosphate export protein YjbB

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Glyoxylate and pyruvate are antagonistic effectors of the Escherichia coli IclR transcriptional regulator. Lorca GL, et al. J Biol Chem, 2007 Jun 1. PMID 17426033
  2. Overproduction and characterization of the iclR gene product of Escherichia coli K-12 and comparison with that of Salmonella typhimurium LT2. Nègre D, et al. Gene, 1991 Jan 2. PMID 1995431
  3. Effect of iclR and arcA deletions on physiology and metabolic fluxes in Escherichia coli BL21 (DE3). Waegeman H, et al. Biotechnol Lett, 2012 Feb. PMID 22009573
  4. Effect of iclR and arcA knockouts on biomass formation and metabolic fluxes in Escherichia coli K12 and its implications on understanding the metabolism of Escherichia coli BL21 (DE3). Waegeman H, et al. BMC Microbiol, 2011 Apr 11. PMID 21481254, Free PMC Article
  5. Kinetic modeling of ace operon genetic regulation in Escherichia coli. Peskov K, et al. J Bioinform Comput Biol, 2008 Oct. PMID 18942160

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The results suggest that deletion of arcA, iclR, and tdcC could efficiently increase l-threonine production in E. coli.
    Title: Deletion of arcA, iclR, and tdcC in Escherichia coli to improve l-threonine production.
  2. No significant differences in biomass yields, acetate yields, CO(2) yields and metabolic fluxes could be observed between the wild type strain E. coli BL21 (DE3) and the double-knockout strain E. coli BL21 (DE3) DeltaarcADeltaiclR.
    Title: Effect of iclR and arcA deletions on physiology and metabolic fluxes in Escherichia coli BL21 (DE3).
  3. IclR clearly represses transcription of glyoxylate pathway genes under glucose abundance, a condition in which Crp activation is absent.
    Title: Effect of iclR and arcA knockouts on biomass formation and metabolic fluxes in Escherichia coli K12 and its implications on understanding the metabolism of Escherichia coli BL21 (DE3).
  4. N-terminus verified by Edman degradation on mature peptide
    Title: Preparation and properties of pure, full-length IclR protein of Escherichia coli. Use of time-of-flight mass spectrometry to investigate the problems encountered.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in glyoxylate cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
DNA-binding transcriptional repressor IclR

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4222804..4223628 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418442.2 DNA-binding transcriptional repressor IclR [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418442.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A1V2GKW9, A0A5B9AQU0, A0AAN3P484, A0AAN5ENF8
    Conserved Domains (1) summary
    PRK11569
    Location:1 → 274
    PRK11569; glyoxylate bypass operon transcriptional repressor IclR
Nucleotide Protein
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