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zraS sensor histidine kinase ZraS [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948506, updated on 19-Nov-2025
Official Symbol
zraS
Official Full Name
sensor histidine kinase ZraS
Primary source
ECOCYC:EG10008
Locus tag
b4003
See related
ASAP:ABE-0013088
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3995; hydH
Summary
ZraS belongs to the two component system ZraS/ZraR , is a sensor-histidine kinase and is known to be a transmembrane protein composed of three domains: external sensory domain (amino-terminal), cytoplasmic transmitter domain (carboxyl-terminal) and transmembrane hydrofobic central domain (unknown funtion). [More information is available at EcoCyc: EG10008].
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Sequence:
NC_000913.3 (4201926..4203323)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF1481 domain-containing protein YjaH Neighboring gene signaling pathway modulator ZraP Neighboring gene DNA-binding transcriptional activator ZraR Neighboring gene phosphoribosylamine--glycine ligase Neighboring gene bifunctional AICAR transformylase/IMP cyclohydrolase

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A structure-function study of ZraP and ZraS provides new insights into the two-component system Zra. Taher R, et al. Biochim Biophys Acta Gen Subj, 2021 Mar. PMID 33309686
  2. Biophysical and physiological characterization of ZraP from Escherichia coli, the periplasmic accessory protein of the atypical ZraSR two-component system. Petit-Härtlein I, et al. Biochem J, 2015 Dec 1. PMID 26438879
  3. Genomic analysis of the histidine kinase family in bacteria and archaea. Kim DJ, et al. Microbiology (Reading), 2001 May. PMID 11320123
  4. Initial cloning and sequencing of hydHG, an operon homologous to ntrBC and regulating the labile hydrogenase activity in Escherichia coli K-12. Stoker K, et al. J Bacteriol, 1989 Aug. PMID 2666400, Free PMC Article
  5. The Two-Component System ZraPSR Is a Novel ESR that Contributes to Intrinsic Antibiotic Tolerance in Escherichia coli. Rome K, et al. J Mol Biol, 2018 Dec 7. PMID 30389436

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A structure-function study of ZraP and ZraS provides new insights into the two-component system Zra.
    Title: A structure-function study of ZraP and ZraS provides new insights into the two-component system Zra.
  2. Results demonstrate that the expression of ZraS is induced by antimicrobials to which the mutants are more sensitive, underlying the function of whole ZraPSR system in response to the antimicrobials.
    Title: The Two-Component System ZraPSR Is a Novel ESR that Contributes to Intrinsic Antibiotic Tolerance in Escherichia coli.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphorelay sensor kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphorelay sensor kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein histidine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein histidine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity, transferring phosphorus-containing groups IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to cell envelope stress IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within cellular response to lead ion IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within cellular response to zinc ion IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within peptidyl-histidine phosphorylation ISM
Inferred from Sequence Model
more info
 PubMed 
involved_in phosphorelay signal transduction system IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
sensor histidine kinase ZraS
NP_418431.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4201926..4203323
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418431.1 sensor histidine kinase ZraS

    See identical proteins and their annotated locations for NP_418431.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2X1N4L7
    Conserved Domains (1) summary
    PRK10364
    Location:4 → 465
    PRK10364; two-component system sensor histidine kinase ZraS
Nucleotide Protein
Heading Accession and Version

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