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zraR DNA-binding transcriptional activator ZraR [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948505, updated on 23-Apr-2026
Official Symbol
zraR
Official Full Name
DNA-binding transcriptional activator ZraR
Primary source
ECOCYC:EG10482
Locus tag
b4004
See related
ASAP:ABE-0013093
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3996; hydG
Summary
The N-terminal sequencing of overexpressed protein showed that the fMet is not clipped (Leonhartsberger et al. [More information is available at EcoGene: EG10482]. ZraR, "zinc resistance-associated regulator," controls the expression of genes involved in tolerance to high zinc concentrations. [More information is available at EcoCyc: EG10482].
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Sequence:
NC_000913.3 (4203320..4204645)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF1481 domain-containing protein YjaH Neighboring gene signaling pathway modulator ZraP Neighboring gene sensor histidine kinase ZraS Neighboring gene phosphoribosylamine--glycine ligase Neighboring gene bifunctional AICAR transformylase/IMP cyclohydrolase Neighboring gene 16S ribosomal RNA

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Initial cloning and sequencing of hydHG, an operon homologous to ntrBC and regulating the labile hydrogenase activity in Escherichia coli K-12. Stoker K, et al. J Bacteriol, 1989 Aug. PMID 2666400, Free PMC Article
  2. New insights into [FeFe] hydrogenase activation and maturase function. Kuchenreuther JM, et al. PLoS One, 2012. PMID 23049878, Free PMC Article
  3. The Two-Component System ZraPSR Is a Novel ESR that Contributes to Intrinsic Antibiotic Tolerance in Escherichia coli. Rome K, et al. J Mol Biol, 2018 Dec 7. PMID 30389436
  4. Structures and organisation of AAA+ enhancer binding proteins in transcriptional activation. Schumacher J, et al. J Struct Biol, 2006 Oct. PMID 16531068
  5. In vitro activation of [FeFe] hydrogenase: new insights into hydrogenase maturation. McGlynn SE, et al. J Biol Inorg Chem, 2007 May. PMID 17372774

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphorelay response regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorelay signal transduction system IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphorelay signal transduction system IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of protein-DNA complex IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
DNA-binding transcriptional activator ZraR

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4203320..4204645
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418432.1 DNA-binding transcriptional activator ZraR

    See identical proteins and their annotated locations for NP_418432.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A376FSU1
    Conserved Domains (1) summary
    PRK10365
    Location:1 → 441
    PRK10365; sigma-54-dependent response regulator transcription factor ZraR
Nucleotide Protein
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