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hupA DNA-binding protein HU-alpha [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948499, updated on 11-Oct-2018

Summary

Gene symbol
hupA
Gene description
DNA-binding protein HU-alpha
Primary source
EcoGene:EG10466
Locus tag
b4000
See related
ASAP:ABE-0013077; ECOCYC:EG10466
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3992
Summary
HU concentration in the cell determines the mechanical effect; flexible bends responsible for compaction occur at concentrations <100nM, while increased concentrations result in the formation of a rigid nucleoprotein filament and no significant concentration. [More information is available at EcoGene: EG10466]. HU is a heterodimer formed by an - and a -subunit that are encoded by hupA and hupB genes, respectively. [More information is available at EcoCyc: EG10466].

Genomic context

Sequence:
NC_000913.3 (4200281..4200553)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene endonuclease V Neighboring gene conserved protein YjaG Neighboring gene DUF1481 domain-containing protein YjaH Neighboring gene zinc responsive, periplasmic protein with chaperone activity

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular response to DNA damage stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
transcription, DNA-templated IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
HU-DNA complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
DNA-binding protein HU-alpha

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4200281..4200553
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418428.1 DNA-binding protein HU-alpha [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418428.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P0ACF0
    Conserved Domains (1) summary
    PRK10753
    Location:190
    PRK10753; transcriptional regulator HU subunit alpha; Provisional
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