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murI glutamate racemase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948467, updated on 30-Jul-2025
Official Symbol
murI
Official Full Name
glutamate racemase
Primary source
ECOCYC:EG11204
Locus tag
b3967
See related
ASAP:ABE-0012989
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
dga; ECK3959; glr; yijA
Summary
murI is an essential gene. [More information is available at EcoGene: EG11204].
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Sequence:
NC_000913.3 (4165428..4166285)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional repressor FabR Neighboring gene DUF1422 domain-containing inner membrane protein YijD Neighboring gene tRNA m(5)U54 methyltransferase Neighboring gene cobalamin outer membrane transporter Neighboring gene 16S ribosomal RNA Neighboring gene tRNA-Glu

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Exploitation of structural and regulatory diversity in glutamate racemases. Lundqvist T, et al. Nature, 2007 Jun 14. PMID 17568739
  2. Identification of the Escherichia coli murI gene, which is required for the biosynthesis of D-glutamic acid, a specific component of bacterial peptidoglycan. Doublet P, et al. J Bacteriol, 1992 Sep. PMID 1355768, Free PMC Article
  3. UDP-N-acetylmuramyl-L-alanine functions as an activator in the regulation of the Escherichia coli glutamate racemase activity. Ho HT, et al. Biochemistry, 1995 Feb 28. PMID 7873525
  4. Expression of glr (murI, dga) gene encoding glutamate racemase in Escherichia coli. Yoshimura T, et al. J Biol Chem, 1993 Nov 15. PMID 7901215
  5. The murI gene of Escherichia coli is an essential gene that encodes a glutamate racemase activity. Doublet P, et al. J Bacteriol, 1993 May. PMID 8098327, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables amino-acid racemase activity IEA
Inferred from Electronic Annotation
more info
  
enables glutamate racemase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutamate racemase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutamate racemase activity IEA
Inferred from Electronic Annotation
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables racemase and epimerase activity, acting on amino acids and derivatives IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidoglycan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidoglycan biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within peptidoglycan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell shape IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
glutamate racemase
NP_418402.2

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4165428..4166285
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418402.2 glutamate racemase

    See identical proteins and their annotated locations for NP_418402.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1X3J9Y8
    Conserved Domains (1) summary
    PRK00865
    Location:17 → 281
    PRK00865; glutamate racemase; Provisional
Nucleotide Protein
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