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argH argininosuccinate lyase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948463, updated on 30-Jul-2025
Official Symbol
argH
Official Full Name
argininosuccinate lyase
Primary source
ECOCYC:EG11223
Locus tag
b3960
See related
ASAP:ABE-0012969
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3951
Summary
Argininosuccinate lyase catalyzes the final step in the L-arginine biosynthesis pathway. [More information is available at EcoCyc: EG11223].
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Sequence:
NC_000913.3 (4156850..4158223)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene N-acetylglutamylphosphate reductase Neighboring gene acetylglutamate kinase Neighboring gene ncRNA Neighboring gene DNA-binding transcriptional dual regulator OxyR Neighboring gene soluble pyridine nucleotide transhydrogenase

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Dual regulation by arginine of the expression of the Escherichia coli argECBH operon. Kryzek RA, et al. J Bacteriol, 1976 Apr. PMID 770426, Free PMC Article
  2. The determination by radiochemical assay of argininosuccinase produced in an Escherichia coli system in vitro. Zidwick MJ, et al. Biochem J, 1982 Dec 1. PMID 6762207, Free PMC Article
  3. Structure determination and refinement at 2.44 A resolution of argininosuccinate lyase from Escherichia coli. Bhaumik P, et al. Acta Crystallogr D Biol Crystallogr, 2004 Nov. PMID 15502303
  4. Stationary phase expression of the arginine biosynthetic operon argCBH in Escherichia coli. Weerasinghe JP, et al. BMC Microbiol, 2006 Feb 22. PMID 16504055, Free PMC Article
  5. Nucleotide sequence of Escherichia coli argB and argC genes: comparison of N-acetylglutamate kinase and N-acetylglutamate-gamma-semialdehyde dehydrogenase with homologous and analogous enzymes. Parsot C, et al. Gene, 1988 Sep 7. PMID 2851495

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. crystal structure of argininosuccinate lyase
    Title: Structure determination and refinement at 2.44 A resolution of argininosuccinate lyase from Escherichia coli.
Submit: New GeneRIF Correction

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables argininosuccinate lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables argininosuccinate lyase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables argininosuccinate lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-arginine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in L-arginine biosynthetic process via ornithine IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-arginine biosynthetic process via ornithine IEA
Inferred from Electronic Annotation
more info
  
involved_in amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
argininosuccinate lyase
NP_418395.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4156850..4158223
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418395.1 argininosuccinate lyase

    See identical proteins and their annotated locations for NP_418395.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2X3KKI2
    Conserved Domains (1) summary
    PRK04833
    Location:1 → 455
    PRK04833; argininosuccinate lyase; Provisional
Nucleotide Protein
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Gene LinkOut

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