oxyR [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

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Official Symbol: oxyR
Primary source: ASAP:ABE-0012973
Locus tag: b3961
See related: ECOCYC:EG10681
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK3953; momR; mor
Summary: This regulator belongs to the LysR family and participates in controlling several genes involved in the response to oxidative stress and the production of surface proteins that control colony morphology and autoaggregation ability. [More information is available at EcoCyc: EG10681].
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Genomic context

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Sequence:: NC_000913.3 (4158490..4159407)

NC_000913.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:: NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

OxyR Is a Convergent Target for Mutations Acquired during Adaptation to Oxidative Stress-Prone Metabolic States.
Title: OxyR Is a Convergent Target for Mutations Acquired during Adaptation to Oxidative Stress-Prone Metabolic States.
The authors have determined how ElaB is regulated under oxidative stress: RpoS and OxyR coordinately control the expression of inner membrane protein ElaB.
Title: Resistance to oxidative stress by inner membrane protein ElaB is regulated by OxyR and RpoS.
Constitutive expression of the OxyR regulon confers the maximum HOCl resistance.
Title: Evolution of Escherichia coli for maximum HOCl resistance through constitutive expression of the OxyR regulon.
The isogenic oxyR mutant exhibited increased H2O2 sensitivity, indistinguishable in vitro growth, and attenuated virulence in rodent models of urinary tract, subcutaneous infection, and systemic sepsis.
Title: OxyR contributes to the virulence of a Clonal Group A Escherichia coli strain (O17:K+:H18) in animal models of urinary tract infection, subcutaneous infection, and systemic sepsis.
Oxidative stress response proteins such as AhpF, Dps, and Fur, all of which belong to the oxyR regulon, were upregulated in Escherichia coli isolates from mice fed the lactose-rich diet.
Title: Impact of nutritional factors on the proteome of intestinal Escherichia coli: induction of OxyR-dependent proteins AhpF and Dps by a lactose-rich diet.
OxyR serves as a master regulator of S-nitrosylation, and alternative posttranslational modifications of OxyR control distinct transcriptional responses
Title: Endogenous protein S-Nitrosylation in E. coli: regulation by OxyR.
OxyR seems to be a factor stimulating lambda prophage maintenance under conditions of oxidative stress.
Title: Influence of the Escherichia coli oxyR gene function on lambda prophage maintenance.
Data suggest that the redox state of OxyR and Fnr modulates their interaction with the vgb promoter.
Title: Redox-mediated interactions of VHb (Vitreoscilla haemoglobin) with OxyR: novel regulation of VHb biosynthesis under oxidative stress.
The data support a model in which in an ON-phase cell, the subcellular OxyR availability at the replication fork as it passes through the agn43 regulatory region is key for initiating an ON-to-OFF switch.
Title: Establishing and maintaining sequestration of Dam target sites for phase variation of agn43 in Escherichia coli.
deletion mutant strains fail to enhance oxidative stress resistance following treatment with tannin and quercetin
Title: Influence of polyphenols on Escherichia coli resistance to oxidative stress.

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General gene information

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Gene Ontology Provided by EcoCyc

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-templated transcription initiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to nitrosative stress	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to oxidative stress	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
part_of protein-DNA complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: DNA-binding transcriptional dual regulator OxyR

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_000913.3 Reference assembly

Range

4158490..4159407

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NP_418396.1 DNA-binding transcriptional dual regulator OxyR [Escherichia coli str. K-12 substr. MG1655]

See identical proteins and their annotated locations for NP_418396.1

Status: PROVISIONAL

UniProtKB/TrEMBL

A0A2W6P981, A0A6N0IJR7

Conserved Domains (1) summary

PRK11151
Location:1 → 305

PRK11151; DNA-binding transcriptional regulator OxyR; Provisional