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fabR DNA-binding transcriptional repressor FabR [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948460, updated on 26-Mar-2025
Official Symbol
fabR
Official Full Name
DNA-binding transcriptional repressor FabR
Primary source
ECOCYC:EG11394
Locus tag
b3963
See related
ASAP:ABE-0012979
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3955; yijC
Summary
TetR family. [More information is available at EcoGene: EG11394]. FabR, "fatty acid biosynthesis regulator," regulates the expression of genes involved in the synthesis of unsaturated fatty acids . [More information is available at EcoCyc: EG11394].
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Sequence:
NC_000913.3 (4161067..4161771)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene DNA-binding transcriptional dual regulator OxyR Neighboring gene soluble pyridine nucleotide transhydrogenase Neighboring gene DUF1422 domain-containing inner membrane protein YijD Neighboring gene tRNA m(5)U54 methyltransferase Neighboring gene cobalamin outer membrane transporter Neighboring gene glutamate racemase

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Physical properties of membrane lipids: biological relevance and regulation. Cronan JE Jr, et al. Bacteriol Rev, 1975 Sep. PMID 1100043, Free PMC Article
  2. Transcriptional regulation of membrane lipid homeostasis in Escherichia coli. Zhu K, et al. J Biol Chem, 2009 Dec 11. PMID 19854834, Free PMC Article
  3. Mechanistic diversity and regulation of Type II fatty acid synthesis. Marrakchi H, et al. Biochem Soc Trans, 2002 Nov. PMID 12440970
  4. The Pfam protein families database. Bateman A, et al. Nucleic Acids Res, 2000 Jan 1. PMID 10592242, Free PMC Article
  5. Regulation of fatty acid metabolism in bacteria. Fujita Y, et al. Mol Microbiol, 2007 Nov. PMID 17919287

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
DNA-binding transcriptional repressor FabR

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4161067..4161771
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418398.3 DNA-binding transcriptional repressor FabR [Escherichia coli str. K-12 substr. MG1655]

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0D6HJK5, A0A0E2LD18, A0A0H3ENR8, A0A0K4WZZ8, A0A7U9IUA8, A0A979H3Z8, B7MIA3, B7MR91, S1NUE8
    Conserved Domains (1) summary
    PRK11202
    Location:20 → 219
    PRK11202; HTH-type transcriptional repressor FabR
Nucleotide Protein
Heading Accession and Version

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