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argC N-acetylglutamylphosphate reductase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948455, updated on 26-Mar-2025
Official Symbol
argC
Official Full Name
N-acetylglutamylphosphate reductase
Primary source
ECOCYC:EG10065
Locus tag
b3958
See related
ASAP:ABE-0012964
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
Arg2; ECK3949
Summary
N-acetylglutamylphosphate reductase (ArgC) carries out the third step in arginine biosynthesis and its subpathway, ornithine biosynthesis. [More information is available at EcoCyc: EG10065].
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Sequence:
NC_000913.3 (4155001..4156005)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene phosphoenolpyruvate carboxylase Neighboring gene acetylornithine deacetylase Neighboring gene acetylglutamate kinase Neighboring gene argininosuccinate lyase

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. N-Acetyl-gamma-Ilutamokinase and N-acetylglutamic gamma-semialdehyde dehydrogenase: repressible enzymes of arginine synthesis in Escherichia coli. BAICH A, et al. Biochem Biophys Res Commun, 1962 Jun 4. PMID 13863980
  2. The C-terminal end of AraC tightly binds to the rest of its domain. Harmer TL, et al. J Biol Chem, 2001 Feb 16. PMID 11104764
  3. The regulatory region of the divergent argECBH operon in Escherichia coli K-12. Piette J, et al. Nucleic Acids Res, 1982 Dec 20. PMID 6761650, Free PMC Article
  4. Promoter mapping and selection of operator mutants by using insertion of bacteriophage Mu in the argECBH divergent operon of Escherichia coli K-12. Beny G, et al. J Bacteriol, 1982 Jul. PMID 6211434, Free PMC Article
  5. Structural and biochemical characterization of the Escherichia coli argE gene product. Meinnel T, et al. J Bacteriol, 1992 Apr. PMID 1551850, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables N-acetyl-gamma-glutamyl-phosphate reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables N-acetyl-gamma-glutamyl-phosphate reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables NADP+ binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within L-arginine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in L-arginine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
N-acetylglutamylphosphate reductase
NP_418393.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4155001..4156005
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418393.1 N-acetylglutamylphosphate reductase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418393.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376TQB9
    Conserved Domains (1) summary
    PRK00436
    Location:1 → 333
    argC; N-acetyl-gamma-glutamyl-phosphate reductase; Validated
Nucleotide Protein
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