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gldA L-1,2-propanediol dehydrogenase/glycerol dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948440, updated on 19-Nov-2025
Official Symbol
gldA
Official Full Name
L-1,2-propanediol dehydrogenase/glycerol dehydrogenase
Primary source
ECOCYC:EG11904
Locus tag
b3945
See related
ASAP:ABE-0012912
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3937
Summary
The enzyme is found in two catalytically active forms, a large form of eight subunits and a small form of two subunits. [More information is available at EcoCyc: EG11904].
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Sequence:
NC_000913.3 (4137932..4139035, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene cystine exporter Neighboring gene DUF1287 domain-containing protein YijF Neighboring gene fructose-6-phosphate aldolase 2 Neighboring gene putative PTS multiphosphoryl transfer protein PtsA

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Formation of D-1-amino-2-propanol from L-threonine by enzymes from Escherichia coli K-12. Campbell RL, et al. Biochem Biophys Res Commun, 1973 Jul 17. PMID 4577583
  2. Derepression of an NAD-linked dehydrogenase that serves an Escherichia coli mutant for growth on glycerol. Tang JC, et al. J Bacteriol, 1982 Dec. PMID 6754692, Free PMC Article
  3. Structure of glycerol dehydrogenase (GldA) from Escherichia coli. Zhang J, et al. Acta Crystallogr F Struct Biol Commun, 2019 Mar 1. PMID 30839292, Free PMC Article
  4. A glycerol dehydrogenase from Escherichia coli. ASNIS RE, et al. J Biol Chem, 1953 Jul. PMID 13069498
  5. D-1-amino-2-propanol:NAD+ oxidoreductase. Purification and general properties of the large molecular form of the enzyme from Escherichia coli K12. Kelley JJ, et al. J Biol Chem, 1984 Feb 25. PMID 6365902

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. this study proposes that the primary role of gldA is to remove toxic dihydroxyacetone by converting it into glycerol.
    Title: Role of GldA in dihydroxyacetone and methylglyoxal metabolism of Escherichia coli K12.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables (R)-aminopropanol dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables (R)-aminopropanol dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycerol dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycerol dehydrogenase (NAD+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glycerol dehydrogenase (NAD+) activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on CH-OH group of donors IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in anaerobic glycerol catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within anaerobic glycerol catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in energy derivation by oxidation of organic compounds IEA
Inferred from Electronic Annotation
more info
  
involved_in glycerol catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycerol metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within methylglyoxal catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein homotetramerization IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
L-1,2-propanediol dehydrogenase/glycerol dehydrogenase
NP_418380.4

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4137932..4139035 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418380.4 L-1,2-propanediol dehydrogenase/glycerol dehydrogenase

    See identical proteins and their annotated locations for NP_418380.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A192CG58, A0A1X3J9V3, A0AA36P881, A0AAN3SDD8, F4T6I3
    Conserved Domains (1) summary
    PRK09423
    Location:1 → 366
    gldA; glycerol dehydrogenase; Provisional
Nucleotide Protein
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