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metB O-succinylhomoserine(thiol)-lyase/O-succinylhomoserine lyase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948434, updated on 6-May-2021

Summary

Gene symbol
metB
Gene description
O-succinylhomoserine(thiol)-lyase/O-succinylhomoserine lyase
Primary source
ASAP:ABE-0012887
Locus tag
b3939
See related
ECOCYC:EG10582
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3931; met-1
Summary
Upregulated by GSNO in defined medium. [More information is available at EcoGene: EG10582].
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Genomic context

Sequence:
NC_000913.3 (4128672..4129832)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative lipid-binding hydrolase YiiX Neighboring gene DNA-binding transcriptional repressor MetJ Neighboring gene fused aspartate kinase/homoserine dehydrogenase 2 Neighboring gene 5,10-methylenetetrahydrofolate reductase

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables carbon-sulfur lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables cystathionine gamma-lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cystathionine gamma-synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cystathionine gamma-synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cystathionine gamma-synthase activity IEA
Inferred from Electronic Annotation
more info
 
enables pyridoxal phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables pyridoxal phosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cysteine biosynthetic process via cystathionine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within methionine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within methionine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transsulfuration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within transsulfuration IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
O-succinylhomoserine(thiol)-lyase/O-succinylhomoserine lyase
NP_418374.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4128672..4129832
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418374.1 O-succinylhomoserine(thiol)-lyase/O-succinylhomoserine lyase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418374.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P00935
    Conserved Domains (1) summary
    PRK08045
    Location:1386
    PRK08045; cystathionine gamma-synthase; Provisional
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