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metL fused aspartate kinase/homoserine dehydrogenase 2 [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948433, updated on 10-Oct-2024

Summary

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Official Symbol
metL
Official Full Name
fused aspartate kinase/homoserine dehydrogenase 2
Primary source
ECOCYC:EG10590
Locus tag
b3940
See related
ASAP:ABE-0012889
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3932; metM
Summary
Aspartate kinase II / homoserine dehydrogenase II (MetL) is a bifunctional enzyme that catalyzes the first step in the biosynthesis of lysine and homoserine, and indirectly methionine and threonine, as well as catalyzing the final step in homoserine biosynthesis. [More information is available at EcoCyc: EG10590].
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Genomic context

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Sequence:
NC_000913.3 (4129835..4132267)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional repressor MetJ Neighboring gene O-succinylhomoserine(thiol)-lyase/O-succinylhomoserine lyase Neighboring gene 5,10-methylenetetrahydrofolate reductase Neighboring gene catalase/hydroperoxidase HPI

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. E. coli aspartokinase II-homoserine dehydrogenase II polypeptide chain has a triglobular structure. Belfaiza J, et al. Biochem Biophys Res Commun, 1984 Aug 30. PMID 6383377
  2. The methionine-repressible homoserine dehydrogenase and aspartokinase activities of Escherichia coli K 12. Preparation of the homogeneous protein catalyzing the two activities. Molecular weight of the native enzyme and of its subunits. Falcoz-Kelly F, et al. Eur J Biochem, 1969 Mar. PMID 4889171
  3. Regulation by methionine of the synthesis of a third aspartokinase and of a second homoserine dehydrogenase in Escherichia coli K 12. Patte JC, et al. Biochim Biophys Acta, 1967 Mar 22. PMID 4860558
  4. Regulation of methionine synthesis in Escherichia coli: effect of metJ gene product and S-adenosylmethionine on the in vitro expression of the metB, metL and metJ genes. Shoeman R, et al. Biochem Biophys Res Commun, 1985 Dec 17. PMID 3910040
  5. Subunit structure of the methionine-repressible aspartokinase II--homoserine dehydrogenase II from Escherichia coli K12. Dautry-Varsat A, et al. Eur J Biochem, 1977 Jun 1. PMID 328280

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: Nucleotide sequence of the metL gene of Escherichia coli. Its product, the bifunctional aspartokinase ii-homoserine dehydrogenase II, and the bifunctional product of the thrA gene, aspartokinase I-homoserine dehydrogenase I, derive from a common ancestor.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables NAD+ binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables NADP binding IEA
Inferred from Electronic Annotation
more info
  
enables aspartate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aspartate kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aspartate kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables homoserine dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables homoserine dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in aspartate family amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in homoserine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within homoserine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lysine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lysine biosynthetic process via diaminopimelate IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lysine biosynthetic process via diaminopimelate IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lysine biosynthetic process via diaminopimelate IEA
Inferred from Electronic Annotation
more info
  
involved_in methionine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in methionine biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in threonine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in threonine biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
fused aspartate kinase/homoserine dehydrogenase 2
NP_418375.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4129835..4132267
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418375.1 fused aspartate kinase/homoserine dehydrogenase 2 [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418375.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0AAN5EVT4
    Conserved Domains (1) summary
    PRK09466
    Location:1 → 810
    metL; bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional
Nucleotide Protein
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