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cytR CytR [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948427, updated on 30-Jul-2025
Official Symbol
cytR
Official Full Name
CytR
Primary source
ECOCYC:EG10200
Locus tag
b3934
See related
ASAP:ABE-0012853
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3926
Summary
This protein negatively controls the expression of the transcription units that encode the proteins and enzymes required for the transport (nupC, nupG, and tsx) and the utilization of nucleosides (deoCABD, udp, and cdd). [More information is available at EcoCyc: EG10200].
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Sequence:
NC_000913.3 (4123431..4124456, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene peptidase component of the HslVU protease Neighboring gene cell division protein FtsN Neighboring gene primosomal protein N' Neighboring gene 50S ribosomal subunit protein L31

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. [Mutational analysis of the CytR protein binding site within the regulatory region of Escherichia coli udp gene]. Domakova EV, et al. Genetika, 1999 Feb. PMID 10495936
  2. CytR/cAMP-CRP nucleoprotein formation in E. coli: the CytR repressor binds its operator as a stable dimer in a ternary complex with cAMP-CRP. Kristensen HH, et al. J Mol Biol, 1996 Jul 12. PMID 8764393
  3. Allosteric mechanism of induction of CytR-regulated gene expression. Cytr repressor-cytidine interaction. Barbier CS, et al. J Biol Chem, 1997 Jul 4. PMID 9202008
  4. DNA-binding characteristics of the Escherichia coli CytR regulator: a relaxed spacing requirement between operator half-sites is provided by a flexible, unstructured interdomain linker. Jørgensen CI, et al. Mol Microbiol, 1998 Jan. PMID 9466254
  5. Nucleotide sequence of the CytR regulatory gene of E. coli K-12. Valentin-Hansen P, et al. Nucleic Acids Res, 1986 Mar 11. PMID 3515317, Free PMC Article

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CytR exhibits features of an electric potential sensor modulating its dimensions and landscape in a unique distance-dependent manner while binding target DNA.
    Title: Tunable order-disorder continuum in protein-DNA interactions.
  2. Results indicate that while CytR forms a well-ordered structure in solution, it is highly dynamic.
    Title: Flexibility and adaptability in binding of E. coli cytidine repressor to different operators suggests a role in differential gene regulation.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding EXP
Inferred from Experiment
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
CytR

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4123431..4124456 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418369.1 CytR

    See identical proteins and their annotated locations for NP_418369.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0H2Z4W2, A0A1X3J9S6
    Conserved Domains (1) summary
    PRK11041
    Location:33 → 341
    PRK11041; DNA-binding transcriptional regulator CytR; Provisional
Nucleotide Protein
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