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fieF Zn(2(+))/Fe(2(+))/Cd(2(+)) exporter [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948413, updated on 19-Feb-2025

Summary

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Official Symbol
fieF
Official Full Name
Zn(2(+))/Fe(2(+))/Cd(2(+)) exporter
Primary source
ECOCYC:EG11873
Locus tag
b3915
See related
ASAP:ABE-0012786
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3907; yiiP
Summary
Relieves iron stress. [More information is available at EcoGene: EG11873]. The YiiP protein is a member of the cation diffusion facilitator (CDF) family of metal cation transporters . [More information is available at EcoCyc: EG11873].
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Genomic context

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Sequence:
NC_000913.3 (4106469..4107371)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene periplasmic protein CpxP Neighboring gene ncRNA Neighboring gene 6-phosphofructokinase 1 Neighboring gene sulfate/thiosulfate ABC transporter periplasmic binding protein Sbp

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Biochemistry. How cells control zinc homeostasis. Nies DH. Science, 2007 Sep 21. PMID 17885121
  2. Binding and transport of metal ions at the dimer interface of the Escherichia coli metal transporter YiiP. Wei Y, et al. J Biol Chem, 2006 Aug 18. PMID 16790427
  3. Structural basis for autoregulation of the zinc transporter YiiP. Lu M, et al. Nat Struct Mol Biol, 2009 Oct. PMID 19749753, Free PMC Article
  4. Thermodynamic studies of the mechanism of metal binding to the Escherichia coli zinc transporter YiiP. Chao Y, et al. J Biol Chem, 2004 Apr 23. PMID 14960568
  5. Oligomeric state of the Escherichia coli metal transporter YiiP. Wei Y, et al. J Biol Chem, 2004 Sep 17. PMID 15258151

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the x-ray structure of YiiP in complex with zinc at 3.8 angstrom resolution
    Title: Structure of the zinc transporter YiiP.
  2. findings suggest that FieF is an iron and zinc efflux system, which would be the first example of iron detoxification by efflux in any organism
    Title: FieF (YiiP) from Escherichia coli mediates decreased cellular accumulation of iron and relieves iron stress.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables cadmium ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cadmium ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cadmium ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ferrous iron transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ferrous iron transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables iron ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc efflux antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc efflux antiporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc:proton antiporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cadmium ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cadmium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular iron ion homeostasis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular zinc ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular zinc ion homeostasis IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in iron ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in iron ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in iron ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in zinc ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in zinc ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in zinc ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Zn(2(+))/Fe(2(+))/Cd(2(+)) exporter

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4106469..4107371
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418350.1 Zn(2(+))/Fe(2(+))/Cd(2(+)) exporter [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418350.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9ANH7, A0A6L7CF37
    Conserved Domains (1) summary
    PRK09509
    Location:1 → 299
    fieF; CDF family cation-efflux pump FieF
Nucleotide Protein
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