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bipA 50S ribosomal subunit assembly factor BipA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948369, updated on 26-Mar-2025

Summary

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Official Symbol
bipA
Official Full Name
50S ribosomal subunit assembly factor BipA
Primary source
ECOCYC:EG11837
Locus tag
b3871
See related
ASAP:ABE-0012648
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3864; typA; yihK
Summary
BipA is a member of the ribosome-binding GTPase superfamily. [More information is available at EcoCyc: EG11837].
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Genomic context

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Sequence:
NC_000913.3 (4058407..4060230)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein histidine kinase NtrB Neighboring gene glutamine synthetase Neighboring gene putative DNA-binding transcriptional regulator YihL Neighboring gene putative TIM barrel domain-containing protein YihM

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The GTPase BipA expressed at low temperature in Escherichia coli assists ribosome assembly and has chaperone-like activity. Choi E, et al. J Biol Chem, 2018 Nov 23. PMID 30305394, Free PMC Article
  2. Salmonella typhimurium responses to a bactericidal protein from human neutrophils. Qi SY, et al. Mol Microbiol, 1995 Aug. PMID 8559071
  3. Tyrosine phosphorylation in Escherichia coli. Freestone P, et al. J Mol Biol, 1998 Jun 26. PMID 9642082
  4. BipA affects Ca++ fluxes and phosphorylation of the translocated intimin receptor (Tir/Hp90) in host epithelial cells infected with enteropathogenic E. coli. Farris M, et al. Biochem Soc Trans, 1998 Aug. PMID 9765944
  5. Regulation of the Escherichia coli K5 capsule gene cluster: evidence for the roles of H-NS, BipA, and integration host factor in regulation of group 2 capsule gene clusters in pathogenic E. coli. Rowe S, et al. J Bacteriol, 2000 May. PMID 10781541, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. BipA expression was significantly stimulated at 20 degrees C, suggesting that it encodes a cold shock-inducible GTPase.
    Title: The GTPase BipA expressed at low temperature in Escherichia coli assists ribosome assembly and has chaperone-like activity.
  2. N-terminus verified by Edman degradation on complete protein
    Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables guanosine tetraphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanosine tetraphosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein folding chaperone IDA
Inferred from Direct Assay
more info
 PubMed 
enables rRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables ribosome binding IEA
Inferred from Electronic Annotation
more info
  
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to cold IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to cold IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosomal large subunit assembly IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ribosomal large subunit assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within translation IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
50S ribosomal subunit assembly factor BipA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4058407..4060230
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_026274.1 50S ribosomal subunit assembly factor BipA [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for YP_026274.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A775YXG6, A0A826J2W3, A0A830SKM2
    Conserved Domains (1) summary
    COG1217
    Location:1 → 604
    TypA; Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]
Nucleotide Protein
Heading Accession and Version

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