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glnG [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948361, updated on 11-Sep-2024

Summary

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Official Symbol
glnG
Primary source
ECOCYC:EG10385
Locus tag
b3868
See related
ASAP:ABE-0012632
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3861; glnT; ntrC
Summary
NtrC is a member of the 54-dependent activator family and belongs to the two-component system NtrB/NtrC . [More information is available at EcoCyc: EG10385].
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Genomic context

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Sequence:
NC_000913.3 (4053869..4055278, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene coproporphyrinogen III dehydrogenase Neighboring gene uncharacterized protein YshB Neighboring gene protein histidine kinase NtrB Neighboring gene glutamine synthetase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nitrogen and carbon status are integrated at the transcriptional level by the nitrogen regulator NtrC in vivo. Schumacher J, et al. mBio, 2013 Nov 19. PMID 24255125, Free PMC Article
  2. Segmented transition pathway of the signaling protein nitrogen regulatory protein C. Lei M, et al. J Mol Biol, 2009 Sep 25. PMID 19576227, Free PMC Article
  3. The structural basis for regulated assembly and function of the transcriptional activator NtrC. De Carlo S, et al. Genes Dev, 2006 Jun 1. PMID 16751184, Free PMC Article
  4. Evidence for a second interaction between the regulatory amino-terminal and central output domains of the response regulator NtrC (nitrogen regulator I) in Escherichia coli. Harrod AC, et al. J Biol Chem, 2004 Jan 23. PMID 14563853
  5. Regulation of the transcriptional activator NtrC1: structural studies of the regulatory and AAA+ ATPase domains. Lee SY, et al. Genes Dev, 2003 Oct 15. PMID 14561776, Free PMC Article

See all (66) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The results reveal that nitrogen-starved Escherichia coli synthesizes (p)ppGpp and forms a higher percentage of persister cells than nonstarved cells and that both NtrC and RelA are important for these processes.
    Title: Nitrogen Starvation Induces Persister Cell Formation in Escherichia coli.
  2. Transcription of relA, a key gene responsible for the synthesis of ppGpp, is activated by NtrC during nitrogen starvation.
    Title: Nitrogen stress response and stringent response are coupled in Escherichia coli.
  3. Authors show that the dominant role of NtrC is to regulate glnA transcription and its own expression, indicating that the glutamine paradox is not due to NtrC-independent gene regulation.
    Title: Nitrogen and carbon status are integrated at the transcriptional level by the nitrogen regulator NtrC in vivo.
  4. Results determine a possible pathway of interconversion between the active state and the inactive state of nitrogen regulatory protein C by targeted molecular dynamics simulations.
    Title: Segmented transition pathway of the signaling protein nitrogen regulatory protein C.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphorelay response regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in nitrogen fixation IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphorelay signal transduction system IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of nitrogen utilization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
DNA-binding transcriptional dual regulator NtrC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4053869..4055278 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418304.1 DNA-binding transcriptional dual regulator NtrC [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418304.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8H9XXD4
    Conserved Domains (1) summary
    PRK10923
    Location:1 → 469
    glnG; nitrogen regulation protein NR(I); Provisional
Nucleotide Protein
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