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xerC site-specific tyrosine recombinase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948355, updated on 30-Jul-2025
Official Symbol
xerC
Official Full Name
site-specific tyrosine recombinase
Primary source
ECOCYC:EG11069
Locus tag
b3811
See related
ASAP:ABE-0012448
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3806
Summary
XerCD acts at the Dif site. [More information is available at EcoGene: EG11069]. XerC is part of the Xer site-specific recombination system . [More information is available at EcoCyc: EG11069].
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Sequence:
NC_000913.3 (3996287..3997183)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene LptD oxidative maturation-associated lipoprotein Neighboring gene diaminopimelate epimerase Neighboring gene DUF484 domain-containing protein YigA Neighboring gene 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase Neighboring gene DNA helicase II

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Xer site-specific recombination. DNA strand rejoining by recombinase XerC. Grainge I, et al. J Biol Chem, 1999 Mar 5. PMID 10037776
  2. Osmoregulation of dimer resolution at the plasmid pJHCMW1 mwr locus by Escherichia coli XerCD recombination. Pham H, et al. J Bacteriol, 2002 Mar. PMID 11872712, Free PMC Article
  3. Determinants of selectivity in Xer site-specific recombination. Blakely G, et al. Genes Dev, 1996 Mar 15. PMID 8598302
  4. Binding and cleavage of nicked substrates by site-specific recombinases XerC and XerD. Blakely GW, et al. J Mol Biol, 1997 Jan 10. PMID 8995522
  5. DNA sequence of recombinase-binding sites can determine Xer site-specific recombination outcome. Blake JA, et al. Mol Microbiol, 1997 Jan. PMID 9044272

See all (69) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FtsKgamma interacts with the C-terminal domain of XerD, above a cleft where XerC is thought to bind. We present a model for activation of recombination based on structural data.
    Title: Activation of Xer-recombination at dif: structural basis of the FtsKγ-XerD interaction.
  2. e reveal a physical and functional interaction between Topo IV and the XerCD recombinases acting at the dif site. This interaction is modulated by MatP, a protein involved in the organization of the Ter macrodomain. These results show that Topo IV, XerCD/dif and MatP are part of a network dedicated to the final step of chromosome management during the cell cycle.
    Title: Mapping Topoisomerase IV Binding and Activity Sites on the E. coli Genome.
  3. FtsK translocase has a role in assembly, translocation, and activation of XerCD-dif recombination
    Title: Assembly, translocation, and activation of XerCD-dif recombination by FtsK translocase analyzed in real-time by FRET and two-color tethered fluorophore motion.
  4. Data indicate that the arrival of the FtsK translocase at an initial synaptic complex, forming a transient activated complex in which XerD exchanged a pair of strands to form an Holliday junctions (HJ) intermediate for catalysis by XerC.
    Title: Conformational transitions during FtsK translocase activation of individual XerCD-dif recombination complexes.
  5. N-terminus verified by Edman degradation on complete protein
    Title: Recombination at ColE1 cer requires the Escherichia coli xerC gene product, a member of the lambda integrase family of site-specific recombinases.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables site-specific recombinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables site-specific recombinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables tyrosine-based site-specific recombinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tyrosine-based site-specific recombinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables tyrosine-based site-specific recombinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA integration IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA transposition IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromosome segregation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chromosome segregation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within plasmid maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within plasmid recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in resolution of DNA recombination intermediates IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within resolution of DNA recombination intermediates IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in resolution of DNA recombination intermediates IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of Holliday junction resolvase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Holliday junction resolvase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
site-specific tyrosine recombinase

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3996287..3997183
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418256.1 site-specific tyrosine recombinase

    See identical proteins and their annotated locations for NP_418256.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5B9AR83
    Conserved Domains (1) summary
    COG4973
    Location:4 → 297
    XerC; Site-specific recombinase XerC [Replication, recombination and repair]
Nucleotide Protein
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