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srkA stress response kinase A [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948346, updated on 23-Apr-2026
Official Symbol
srkA
Official Full Name
stress response kinase A
Primary source
ECOCYC:EG11831
Locus tag
b3859
See related
ASAP:ABE-0012604
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3851; orfA; yihE
Summary
rdoA is required for long-term cell survival and for the expression of surface appendages (Zheng, 2007). [More information is available at EcoGene: EG11831]. YihE is a serine/threonine protein kinase that is able to autophosphorylate at serine and threonine, but not tyrosine residues. [More information is available at EcoCyc: EG11831].
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Sequence:
NC_000913.3 (4042415..4043401)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene molybdopterin-guanine dinucleotide biosynthesis adaptor protein Neighboring gene molybdenum cofactor guanylyltransferase Neighboring gene DUF1040 domain-containing protein YihD Neighboring gene thiol:disulfide oxidoreductase DsbA Neighboring gene DUF945 domain-containing protein YihF

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The role of the Shigella flexneri yihE gene in LPS synthesis and virulence. Edwards-Jones B, et al. Microbiology (Reading), 2004 Apr. PMID 15073317
  2. YihE kinase is a central regulator of programmed cell death in bacteria. Dorsey-Oresto A, et al. Cell Rep, 2013 Feb 21. PMID 23416055, Free PMC Article
  3. Analysis of the Escherichia coli genome. III. DNA sequence of the region from 87.2 to 89.2 minutes. Plunkett G 3rd, et al. Nucleic Acids Res, 1993 Jul 25. PMID 8346018, Free PMC Article
  4. Salmonella enterica serovar typhimurium rdoA is growth phase regulated and involved in relaying Cpx-induced signals. Suntharalingam P, et al. J Bacteriol, 2003 Jan. PMID 12511488, Free PMC Article
  5. Influence of the yihE gene of Shigella flexneri on global gene expression: on analysis using DNA arrays. Li MS, et al. Biochem Biophys Res Commun, 2001 Oct 19. PMID 11594757

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within response to stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm EXP
Inferred from Experiment
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
stress response kinase A
NP_418296.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4042415..4043401
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418296.1 stress response kinase A

    See identical proteins and their annotated locations for NP_418296.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A376X783, A0A8S7RCL1
    Conserved Domains (1) summary
    PRK11768
    Location:1 → 324
    PRK11768; serine/threonine protein kinase
Nucleotide Protein
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