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fadB multifunctional enoyl-CoA hydratase, 3-hydroxyacyl-CoA epimerase, Delta(3)-cis- Delta(2)-trans-enoyl-CoA isomerase, L-3-hydroxyacyl-CoA dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948336, updated on 9-Mar-2022

Summary

Gene symbol
fadB
Gene description
multifunctional enoyl-CoA hydratase, 3-hydroxyacyl-CoA epimerase, Delta(3)-cis- Delta(2)-trans-enoyl-CoA isomerase, L-3-hydroxyacyl-CoA dehydrogenase
Primary source
ASAP:ABE-0012564
Locus tag
b3846
See related
ECOCYC:EG10279
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3838; oldB
Summary
FadR regulon. [More information is available at EcoGene: EG10279]. The alpha subunit has four enzymatic activities associated with it. [More information is available at EcoCyc: EG10279].
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Genomic context

Sequence:
NC_000913.3 (4028782..4030971, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene NAD(P)H-flavin reductase Neighboring gene 3-ketoacyl-CoA thiolase Neighboring gene Xaa-Pro dipeptidase Neighboring gene IMPACT family member YigZ Neighboring gene K(+) transporter TrkH

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables 3-hydroxyacyl-CoA dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables 3-hydroxyacyl-CoA dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
enables 3-hydroxyacyl-CoA dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables 3-hydroxybutyryl-CoA epimerase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables 3-hydroxybutyryl-CoA epimerase activity IEA
Inferred from Electronic Annotation
more info
 
enables 3-hydroxybutyryl-CoA epimerase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables NAD+ binding IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables delta(3)-delta(2)-enoyl-CoA isomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables delta(3)-delta(2)-enoyl-CoA isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables enoyl-CoA hydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables enoyl-CoA hydratase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables enoyl-CoA hydratase activity IEA
Inferred from Electronic Annotation
more info
 
enables enoyl-CoA hydratase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables long-chain-3-hydroxyacyl-CoA dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in fatty acid beta-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within fatty acid beta-oxidation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in fatty acid beta-oxidation IEA
Inferred from Electronic Annotation
more info
 
involved_in fatty acid catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of fatty acid beta-oxidation multienzyme complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of fatty acid beta-oxidation multienzyme complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
multifunctional enoyl-CoA hydratase, 3-hydroxyacyl-CoA epimerase, Delta(3)-cis- Delta(2)-trans-enoyl-CoA isomerase, L-3-hydroxyacyl-CoA dehydrogenase
NP_418288.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4028782..4030971 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418288.1 multifunctional enoyl-CoA hydratase, 3-hydroxyacyl-CoA epimerase, Delta(3)-cis- Delta(2)-trans-enoyl-CoA isomerase, L-3-hydroxyacyl-CoA dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418288.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P21177
    Conserved Domains (1) summary
    PRK11730
    Location:1715
    fadB; fatty acid oxidation complex subunit alpha FadB