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fadB [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948336, updated on 24-Aug-2024

Summary

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Official Symbol
fadB
Primary source
ECOCYC:EG10279
Locus tag
b3846
See related
ASAP:ABE-0012564
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3838; oldB
Summary
FadR regulon. [More information is available at EcoGene: EG10279]. The alpha subunit has four enzymatic activities associated with it. [More information is available at EcoCyc: EG10279].
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Genomic context

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Sequence:
NC_000913.3 (4028782..4030971, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene NAD(P)H-flavin reductase Neighboring gene 3-ketoacyl-CoA thiolase Neighboring gene Xaa-Pro dipeptidase Neighboring gene IMPACT family member YigZ Neighboring gene K(+) transporter TrkH

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Glutamate-119 of the large alpha-subunit is the catalytic base in the hydration of 2-trans-enoyl-coenzyme A catalyzed by the multienzyme complex of fatty acid oxidation from Escherichia coli. He XY, et al. Biochemistry, 1997 Sep 9. PMID 9283097
  2. Importance of the gamma-carboxyl group of glutamate-462 of the large alpha-subunit for the catalytic function and the stability of the multienzyme complex of fatty acid oxidation from Escherichia coli. He XY, et al. Biochemistry, 1997 Jan 7. PMID 8993342
  3. Histidine-450 is the catalytic residue of L-3-hydroxyacyl coenzyme A dehydrogenase associated with the large alpha-subunit of the multienzyme complex of fatty acid oxidation from Escherichia coli. He XY, et al. Biochemistry, 1996 Jul 23. PMID 8755745
  4. Glutamate 139 of the large alpha-subunit is the catalytic base in the dehydration of both D- and L-3-hydroxyacyl-coenzyme A but not in the isomerization of delta 3, delta 2-enoyl-coenzyme A catalyzed by the multienzyme complex of fatty acid oxidation from Escherichia coli. Yang SY, et al. Biochemistry, 1995 May 16. PMID 7756275
  5. Multienzyme complexes of fatty acid oxidation from Escherichia coli K12 and from a mutant with a defective L-3-hydroxyacyl coenzyme A dehydrogenase. Pramanik A, et al. Biochim Biophys Acta, 1983 Jan 7. PMID 6402028

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: Nucleotide sequence of the fadA gene. Primary structure of 3-ketoacyl-coenzyme A thiolase from Escherichia coli and the structural organization of the fadAB operon.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 3-hydroxyacyl-CoA dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3-hydroxyacyl-CoA dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables 3-hydroxyacyl-CoA dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables 3-hydroxybutyryl-CoA epimerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3-hydroxybutyryl-CoA epimerase activity IEA
Inferred from Electronic Annotation
more info
  
enables 3-hydroxybutyryl-CoA epimerase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables NAD+ binding IEA
Inferred from Electronic Annotation
more info
  
enables delta(3)-delta(2)-enoyl-CoA isomerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables delta(3)-delta(2)-enoyl-CoA isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables enoyl-CoA hydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables enoyl-CoA hydratase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables enoyl-CoA hydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables enoyl-CoA hydratase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables long-chain-3-hydroxyacyl-CoA dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid beta-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within fatty acid beta-oxidation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in fatty acid beta-oxidation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in fatty acid beta-oxidation IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of fatty acid beta-oxidation multienzyme complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of fatty acid beta-oxidation multienzyme complex IEA
Inferred from Electronic Annotation
more info
  
part_of fatty acid beta-oxidation multienzyme complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
multifunctional enoyl-CoA hydratase, 3-hydroxyacyl-CoA epimerase, Delta(3)-cis- Delta(2)-trans-enoyl-CoA isomerase, L-3-hydroxyacyl-CoA dehydrogenase
NP_418288.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4028782..4030971 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418288.1 multifunctional enoyl-CoA hydratase, 3-hydroxyacyl-CoA epimerase, Delta(3)-cis- Delta(2)-trans-enoyl-CoA isomerase, L-3-hydroxyacyl-CoA dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418288.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7EJH1
    Conserved Domains (1) summary
    PRK11730
    Location:1 → 715
    fadB; fatty acid oxidation complex subunit alpha FadB
Nucleotide Protein
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