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metR DNA-binding transcriptional dual regulator MetR [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948310, updated on 26-Mar-2025

Summary

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Official Symbol
metR
Official Full Name
DNA-binding transcriptional dual regulator MetR
Primary source
ECOCYC:EG10591
Locus tag
b3828
See related
ASAP:ABE-0012506
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3822
Summary
Upregulated by GSNO in defined medium. [More information is available at EcoGene: EG10591].
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Genomic context

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Sequence:
NC_000913.3 (4011863..4012816, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene lysophospholipase L2 Neighboring gene phosphosugar phosphatase YigL Neighboring gene biotin transporter Neighboring gene cobalamin-independent homocysteine transmethylase Neighboring gene putative dienelactone hydrolase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A new methionine locus, metR, that encodes a trans-acting protein required for activation of metE and metH in Escherichia coli and Salmonella typhimurium. Urbanowski ML, et al. J Bacteriol, 1987 Apr. PMID 3549685, Free PMC Article
  2. Structure-function studies on Escherichia coli MetR protein, a putative prokaryotic leucine zipper protein. Maxon ME, et al. Proc Natl Acad Sci U S A, 1990 Sep. PMID 2205852, Free PMC Article
  3. RNA polymerase, PurR and MetR interactions at the glyA promoter of Escherichia coli. Lorenz E, et al. Microbiology (Reading), 1996 Jul. PMID 8757744
  4. The effect of homocysteine on MetR regulation of metE, metR and metH expression in vitro. Cai XY, et al. Biochem Biophys Res Commun, 1989 Aug 30. PMID 2673243
  5. Characterization of the MetR binding sites for the glyA gene of Escherichia coli. Lorenz E, et al. J Bacteriol, 1995 Jul. PMID 7608086, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: Regulation of methionine synthesis in Escherichia coli: effect of the MetR protein on the expression of the metE and metR genes.
  2. required for activation of glyA by CsgD in Escherichia coli K-12.
    Title: Role of MetR and PurR in the activation of glyA by CsgD in Escherichia coli K-12.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables amino acid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in methionine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA-binding transcriptional dual regulator MetR

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4011863..4012816 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418272.1 DNA-binding transcriptional dual regulator MetR [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418272.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376RTN4, A0A8T3UTM4
    Conserved Domains (1) summary
    PRK15421
    Location:1 → 317
    PRK15421; HTH-type transcriptional regulator MetR
Nucleotide Protein
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