U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

rffH glucose-1-phosphate thymidylyltransferase 2 [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948299, updated on 30-Jul-2025
Official Symbol
rffH
Official Full Name
glucose-1-phosphate thymidylyltransferase 2
Primary source
ECOCYC:EG11454
Locus tag
b3789
See related
ASAP:ABE-0012379
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3781; yifG
Try the new Gene page
Try the new Transcripts and proteins table
Sequence:
NC_000913.3 (3973608..3974489)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene UDP-N-acetylglucosamine 2-epimerase Neighboring gene UDP-N-acetyl-D-mannosamine dehydrogenase Neighboring gene dTDP-glucose 4,6-dehydratase 2 Neighboring gene dTDP-4-amino-4,6-dideoxy-D-galactose acyltransferase Neighboring gene dTDP-4-dehydro-6-deoxy-D-glucose transaminase Neighboring gene lipid IIIECA flippase Neighboring gene TDP-N-acetylfucosamine:lipid II N-acetylfucosaminyltransferase

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Crystal structure of Escherichia coli glucose-1-phosphate thymidylyltransferase (RffH) complexed with dTTP and Mg2+. Sivaraman J, et al. J Biol Chem, 2002 Nov 15. PMID 12171937
  2. Genetic analysis of the dTDP-rhamnose biosynthesis region of the Escherichia coli VW187 (O7:K1) rfb gene cluster: identification of functional homologs of rfbB and rfbA in the rff cluster and correct location of the rffE gene. Marolda CL, et al. J Bacteriol, 1995 Oct. PMID 7559340, Free PMC Article
  3. Structure of the O antigen of Escherichia coli K-12 and the sequence of its rfb gene cluster. Stevenson G, et al. J Bacteriol, 1994 Jul. PMID 7517391, Free PMC Article
  4. Analysis of the Escherichia coli genome: DNA sequence of the region from 84.5 to 86.5 minutes. Daniels DL, et al. Science, 1992 Aug 7. PMID 1379743
  5. Genome-wide screening of genes required for swarming motility in Escherichia coli K-12. Inoue T, et al. J Bacteriol, 2007 Feb. PMID 17122336, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables glucose-1-phosphate thymidylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucose-1-phosphate thymidylyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glucose-1-phosphate thymidylyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within O antigen biosynthetic process EXP
Inferred from Experiment
more info
 PubMed 
involved_in enterobacterial common antigen biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in polysaccharide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in polysaccharide biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in polysaccharide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
glucose-1-phosphate thymidylyltransferase 2
NP_418236.1

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3973608..3974489
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418236.1 glucose-1-phosphate thymidylyltransferase 2

    See identical proteins and their annotated locations for NP_418236.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0AAN3Q1Y7
    Conserved Domains (1) summary
    TIGR01207
    Location:2 → 287
    rmlA; glucose-1-phosphate thymidylyltransferase, short form
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.