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ilvC ketol-acid reductoisomerase (NADP(+)) [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948286, updated on 9-Mar-2022

Summary

Gene symbol
ilvC
Gene description
ketol-acid reductoisomerase (NADP(+))
Primary source
ASAP:ABE-0012331
Locus tag
b3774
See related
ECOCYC:EG10495
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3766
Summary
Acetohydroxy acid isomeroreductase (IlvC) carries out two analogous keto-acid reductoisomerase reactions in the parallel biosynthetic pathways generating isoleucine and valine. [More information is available at EcoCyc: EG10495].
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Genomic context

Sequence:
NC_000913.3 (3957970..3959445)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene threonine deaminase Neighboring gene DNA-binding transcriptional dual regulator IlvY Neighboring gene peptidyl-prolyl cis-trans isomerase C Neighboring gene pseudo

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables 2-dehydropantoate 2-reductase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables NADP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ketol-acid reductoisomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ketol-acid reductoisomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ketol-acid reductoisomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ketol-acid reductoisomerase (NADP(+))
NP_418222.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3957970..3959445
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418222.1 ketol-acid reductoisomerase (NADP(+)) [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418222.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P05793
    Conserved Domains (1) summary
    PRK05225
    Location:2488
    PRK05225; ketol-acid reductoisomerase; Validated