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rbsR [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948266, updated on 11-Sep-2024

Summary

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Official Symbol
rbsR
Primary source
ECOCYC:EG10819
Locus tag
b3753
See related
ASAP:ABE-0012271
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3747
Summary
The transcription factor RbsR, for "Ribose Repressor," is negatively autoregulated and controls the transcription of the operon involved in ribose catabolism and transport . [More information is available at EcoCyc: EG10819].
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Genomic context

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Sequence:
NC_000913.3 (3938227..3939219)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene ribose ABC transporter periplasmic binding protein Neighboring gene ncRNA Neighboring gene ribokinase Neighboring gene putative transporter HsrA Neighboring gene DNA-binding transcriptional regulator YieP Neighboring gene 16S ribosomal RNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Involvement of the ribose operon repressor RbsR in regulation of purine nucleotide synthesis in Escherichia coli. Shimada T, et al. FEMS Microbiol Lett, 2013 Jul. PMID 23651393
  2. Structural homology between rbs repressor and ribose binding protein implies functional similarity. Mauzy CA, et al. Protein Sci, 1992 Jul. PMID 1304370, Free PMC Article
  3. Structural and functional analyses of the repressor, RbsR, of the ribose operon of Escherichia coli. Mauzy CA, et al. Protein Sci, 1992 Jul. PMID 1304369, Free PMC Article
  4. Computational analysis of the transcriptional regulation of pentose utilization systems in the gamma subdivision of Proteobacteria. Laikova ON, et al. FEMS Microbiol Lett, 2001 Dec 18. PMID 11750821
  5. D-ribose metabolism in Escherichia coli K-12: genetics, regulation, and transport. Lopilato JE, et al. J Bacteriol, 1984 May. PMID 6327616, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RbsR is a global regulator for switch control between the de novo synthesis of purine nucleotides and its salvage pathway.
    Title: Involvement of the ribose operon repressor RbsR in regulation of purine nucleotide synthesis in Escherichia coli.
  2. N-terminus verified by Edman degradation on mature peptide
    Title: Structural and functional analyses of the repressor, RbsR, of the ribose operon of Escherichia coli.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of DNA-templated transcription IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA-binding transcriptional dual regulator RbsR

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3938227..3939219
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418209.1 DNA-binding transcriptional dual regulator RbsR [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418209.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376CVZ8, A0A895NWY4
    Conserved Domains (1) summary
    PRK10423
    Location:4 → 330
    PRK10423; transcriptional repressor RbsR; Provisional
Nucleotide Protein
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