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ravA regulatory ATPase RavA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948256, updated on 19-Nov-2025
Official Symbol
ravA
Official Full Name
regulatory ATPase RavA
Primary source
ECOCYC:EG11731
Locus tag
b3746
See related
ASAP:ABE-0012247
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3740; yieN
Summary
In rpoS-regulated operon with viaA. [More information is available at EcoGene: EG11731]. RavA belongs to the MoxR family of AAA+ ATPases. [More information is available at EcoCyc: EG11731].
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Sequence:
NC_000913.3 (3929597..3931093, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional dual regulator AsnC Neighboring gene asparagine synthetase A Neighboring gene protein ViaA Neighboring gene K(+):H(+) symporter Kup Neighboring gene D-ribose pyranase

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The AAA+ ATPase RavA and its binding partner ViaA modulate E. coli aminoglycoside sensitivity through interaction with the inner membrane. Felix J, et al. Nat Commun, 2022 Sep 20. PMID 36127320, Free PMC Article
  2. Assembly principles of a unique cage formed by hexameric and decameric E. coli proteins. Malet H, et al. Elife, 2014 Aug 5. PMID 25097238, Free PMC Article
  3. The MoxR ATPase RavA and its cofactor ViaA interact with the NADH:ubiquinone oxidoreductase I in Escherichia coli. Wong KS, et al. PLoS One, 2014. PMID 24454883, Free PMC Article
  4. Formation of a distinctive complex between the inducible bacterial lysine decarboxylase and a novel AAA+ ATPase. Snider J, et al. J Biol Chem, 2006 Jan 20. PMID 16301313
  5. MoxR AAA+ ATPases: a novel family of molecular chaperones? Snider J, et al. J Struct Biol, 2006 Oct. PMID 16677824

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The AAA+ ATPase RavA and its binding partner ViaA modulate E. coli aminoglycoside sensitivity through interaction with the inner membrane.
    Title: The AAA+ ATPase RavA and its binding partner ViaA modulate E. coli aminoglycoside sensitivity through interaction with the inner membrane.
  2. The structural principles of the LdcI-RavA interaction are being described using molecular modeling.
    Title: Assembly principles of a unique cage formed by hexameric and decameric E. coli proteins.
  3. Data show that the RavA structure provides insights into how five RavA hexamers interact with two LdcI/CadA decamers to form the RavA-LdcI/CadA cage-like structure.
    Title: Structure of RavA MoxR AAA+ protein reveals the design principles of a molecular cage modulating the inducible lysine decarboxylase activity.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
regulatory ATPase RavA
NP_418202.4

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3929597..3931093 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418202.4 regulatory ATPase RavA

    See identical proteins and their annotated locations for NP_418202.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A895NYP4
    Conserved Domains (1) summary
    PRK13531
    Location:1 → 498
    PRK13531; regulatory ATPase RavA; Provisional
Nucleotide Protein
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Gene LinkOut

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Other Literature Sources
Molecular Biology Databases
Research Materials