U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

atpB ATP synthase Fo complex subunit a [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948252, updated on 26-Mar-2025
Official Symbol
atpB
Official Full Name
ATP synthase Fo complex subunit a
Primary source
ECOCYC:EG10099
Locus tag
b3738
See related
ASAP:ABE-0012222
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3731; papD; uncB
Summary
The a subunit of the F0 complex plays a critical role in the proton translocation mechanism . [More information is available at EcoCyc: EG10099].
NEW
Try the new Gene table
Try the new Transcript table
Sequence:
NC_000913.3 (3921236..3922051, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene ATP synthase Fo complex subunit b Neighboring gene ATP synthase Fo complex subunit c Neighboring gene ATP synthase accessory factor AtpI Neighboring gene 16S rRNA m(7)G527 methyltransferase

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Transmembrane topology of Escherichia coli H(+)-ATPase (ATP synthase) subunit a. Yamada H, et al. FEBS Lett, 1996 Jul 15. PMID 8706824
  2. Folding and domain-domain interactions of the chaperone PapD measured by 19F NMR. Bann JG, et al. Biochemistry, 2004 Nov 2. PMID 15504040
  3. The ion channel of F-ATP synthase is the target of toxic organotin compounds. von Ballmoos C, et al. Proc Natl Acad Sci U S A, 2004 Aug 3. PMID 15277681, Free PMC Article
  4. Backbone 1H, 15N and 13C assignments for the subunit a of the E. coli ATP synthase. Dmitriev OY, et al. J Biomol NMR, 2004 Jul. PMID 15213458
  5. The role of transmembrane span 2 in the structure and function of subunit a of the ATP synthase from Escherichia coli. DeLeon-Rangel J, et al. Arch Biochem Biophys, 2003 Oct 1. PMID 13679083

See all (89) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate the juxtaposition of subunits b and a in the ATP synthase.
    Title: Interactions between subunits a and b in the rotary ATP synthase as determined by cross-linking.
  2. Interaction with monomeric subunit c drives insertion of ATP synthase subunit a into the membrane and primes a-c complex formation
    Title: Interaction with monomeric subunit c drives insertion of ATP synthase subunit a into the membrane and primes a-c complex formation.
  3. helices fold back on themselves in a chloroform-methanol-H2O (4:4:1) solvent mixture and then pack at an angle such that the cytoplasmic ends of the polypeptide backbone are significantly displaced from each other.
    Title: Interaction of transmembrane helices in ATP synthase subunit a in solution as revealed by spin label difference NMR.
  4. Data indicate that both the N- and C-terminal domains of PapD must fold into a native conformation prior to the formation of domain-domain interactions.
    Title: Folding and domain-domain interactions of the chaperone PapD measured by 19F NMR.
  5. NMR assignments for the subunit a of the E. coli ATP synthase
    Title: Backbone 1H, 15N and 13C assignments for the subunit a of the E. coli ATP synthase.
  6. molecular probes defined five transmembrane helices, the orientation of the protein in the membrane, and information about the relative exposure of the loops connecting these helices
    Title: Structure and function of subunit a of the ATP synthase of Escherichia coli.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables proton transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables proton-transporting ATP synthase activity, rotational mechanism IBA
Inferred from Biological aspect of Ancestor
more info
  
enables proton-transporting ATP synthase activity, rotational mechanism IEA
Inferred from Electronic Annotation
more info
  
enables proton-transporting ATP synthase activity, rotational mechanism IMP
Inferred from Mutant Phenotype
more info
 PubMed 
contributes_to proton-transporting ATPase activity, rotational mechanism IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in ATP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in proton motive force-driven ATP synthesis IEA
Inferred from Electronic Annotation
more info
  
involved_in proton motive force-driven plasma membrane ATP synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proton motive force-driven plasma membrane ATP synthesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proton motive force-driven plasma membrane ATP synthesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
part_of proton-transporting ATP synthase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proton-transporting ATP synthase complex IEA
Inferred from Electronic Annotation
more info
  
part_of proton-transporting ATP synthase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
Preferred Names
ATP synthase Fo complex subunit a
NP_418194.1

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3921236..3922051 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418194.1 ATP synthase Fo complex subunit a [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418194.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6N0IK99
    Conserved Domains (1) summary
    PRK05815
    Location:38 → 271
    PRK05815; F0F1 ATP synthase subunit A; Validated
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.