ibpA small heat shock protein IbpA [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

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Official Symbol: ibpA
Official Full Name: small heat shock protein IbpA
Primary source: ECOCYC:EG11534
Locus tag: b3687
See related: ASAP:ABE-0012058
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK3679; hslT; htpN
Summary: RpoH regulon. [More information is available at EcoGene: EG11534]. IbpA is a small heat shock protein that binds to aggregated proteins and inclusion bodies formed during heterologous protein expression . [More information is available at EcoCyc: EG11534].
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Genomic context

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Sequence:: NC_000913.3 (3867009..3867422, complement)

NC_000913.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IbpAB small heat shock proteins are not host factors for bacteriophage varphiX174 replication.
Title: IbpAB small heat shock proteins are not host factors for bacteriophage ϕX174 replication.
Escherichia coli small heat shock protein IbpA plays a role in regulating the heat shock response by controlling the translation of sigma[32].
Title: Escherichia coli small heat shock protein IbpA plays a role in regulating the heat shock response by controlling the translation of σ(32).
The mRNA binding-mediated self-regulatory function of small heat shock protein IbpA in gamma-proteobacteria is conferred by a conserved arginine.
Title: The mRNA binding-mediated self-regulatory function of small heat shock protein IbpA in γ-proteobacteria is conferred by a conserved arginine.
Translation of ibpA is controlled by an RNA thermometer in its 5' untranslated region, forming a secondary structure that blocks entry of the ribosome at low temperatures.
Title: Multiple layers of control govern expression of the Escherichia coli ibpAB heat-shock operon.
The authors report that IbpA and IbpB, the sHSPs of Escherichia coli, are substrates for the AAA+ Lon protease.
Title: The IbpA and IbpB small heat-shock proteins are substrates of the AAA+ Lon protease.
The lack of IbpAB proteins in E. coli cells results in endogenous oxidative stress and overproduction of extracellular indole, which inhibits the growth of the biofilm at the air-liquid interface.
Title: Escherichia coli heat-shock proteins IbpA and IbpB affect biofilm formation by influencing the level of extracellular indole.
N-terminus verified by Edman degradation on complete protein
Title: Two novel heat shock genes encoding proteins produced in response to heterologous protein expression in Escherichia coli.
IbpA cooperates with IbpB in stabilization of thermally aggregated proteins in a disaggregation competent state
Title: The small heat shock protein IbpA of Escherichia coli cooperates with IbpB in stabilization of thermally aggregated proteins in a disaggregation competent state.

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General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by EcoCyc

Function	Evidence Code	Pubs
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables mRNA 5'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of translation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein stabilization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to heat	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to heat	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed