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emrD multidrug efflux pump EmrD [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948180, updated on 4-Feb-2026
Official Symbol
emrD
Official Full Name
multidrug efflux pump EmrD
Primary source
ECOCYC:EG11693
Locus tag
b3673
See related
ASAP:ABE-0012011
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3664; yicQ
Summary
Major Facilitator Superfamily (MFS). [More information is available at EcoGene: EG11693]. EmrD is a multidrug efflux protein involved in adaptation to low energy shock (exposure to uncouplers of oxidative phosphorylation) in Escherichia coli . [More information is available at EcoCyc: EG11693].
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Sequence:
NC_000913.3 (3853922..3855106)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene membrane-depolarizing toxin TisB Neighboring gene protein YsdE Neighboring gene uncharacterized protein YidF Neighboring gene inner membrane protein YidG Neighboring gene DUF202 domain-containing inner membrane protein YidH

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. An E. coli gene emrD is involved in adaptation to low energy shock. Naroditskaya V, et al. Biochem Biophys Res Commun, 1993 Oct 29. PMID 8240355
  2. Proton-dependent multidrug efflux systems. Paulsen IT, et al. Microbiol Rev, 1996 Dec. PMID 8987357, Free PMC Article
  3. Inducement and reversal of tetracycline resistance in Escherichia coli K-12 and expression of proton gradient-dependent multidrug efflux pump genes. Viveiros M, et al. Antimicrob Agents Chemother, 2005 Aug. PMID 16048990, Free PMC Article
  4. Growth phase-dependent expression of drug exporters in Escherichia coli and its contribution to drug tolerance. Kobayashi A, et al. J Bacteriol, 2006 Aug. PMID 16885437, Free PMC Article
  5. Structure of the multidrug transporter EmrD from Escherichia coli. Yin Y, et al. Science, 2006 May 5. PMID 16675700, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. x-ray structure of EmrD determined to a resolution of 3.5 angstroms
    Title: Structure of the multidrug transporter EmrD from Escherichia coli.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 
Preferred Names
multidrug efflux pump EmrD

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3853922..3855106
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418129.2 multidrug efflux pump EmrD

    See identical proteins and their annotated locations for NP_418129.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A376RA16
    Conserved Domains (1) summary
    PRK11652
    Location:1 → 394
    emrD; multidrug transporter EmrD
Nucleotide Protein
Heading Accession and Version

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