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trmH tRNA (Gm18) 2'-O-methyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948161, updated on 25-Jan-2024

Summary

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Gene symbol
trmH
Gene description
tRNA (Gm18) 2'-O-methyltransferase
Primary source
ASAP:ABE-0011937
Locus tag
b3651
See related
ECOCYC:EG10967
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3641; spoU
Summary
TrmH is a tRNA 2'-O-methyltransferase that specifically modifies tRNA at position G18 . [More information is available at EcoCyc: EG10967].
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Genomic context

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Sequence:
NC_000913.3 (3824515..3825204)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene RNA polymerase subunit omega Neighboring gene bifunctional (p)ppGpp synthase/hydrolase SpoT Neighboring gene ATP-dependent DNA helicase RecG Neighboring gene glutamate:sodium symporter

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The catalytic domain of topological knot tRNA methyltransferase (TrmH) discriminates between substrate tRNA and nonsubstrate tRNA via an induced-fit process. Ochi A, et al. J Biol Chem, 2013 Aug 30. PMID 23867454, Free PMC Article
  2. Physiological analysis of the role of truB in Escherichia coli: a role for tRNA modification in extreme temperature resistance. Kinghorn SM, et al. Microbiology (Reading), 2002 Nov. PMID 12427942
  3. Identification of new RNA modifying enzymes by iterative genome search using known modifying enzymes as probes. Gustafsson C, et al. Nucleic Acids Res, 1996 Oct 1. PMID 8871555, Free PMC Article
  4. Three modifications in the D and T arms of tRNA influence translation in Escherichia coli and expression of virulence genes in Shigella flexneri. Urbonavicius J, et al. J Bacteriol, 2002 Oct. PMID 12218021, Free PMC Article
  5. Characterization of the spoT gene of Escherichia coli. Sarubbi E, et al. J Biol Chem, 1989 Sep 5. PMID 2549050

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA (guanine(18)-2'-O)-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA guanine ribose methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA guanine ribose methylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within tRNA guanine ribose methylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA methylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within tRNA methylation TAS
Traceable Author Statement
more info
 PubMed 
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tRNA (Gm18) 2'-O-methyltransferase
NP_418108.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3824515..3825204
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418108.1 tRNA (Gm18) 2'-O-methyltransferase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418108.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376JQU7, A0A3K0WCF1, A0A5D8M9V8, A0A8S7VJT8
    Conserved Domains (1) summary
    PRK11081
    Location:1 → 228
    PRK11081; tRNA guanosine-2'-O-methyltransferase; Provisional
Nucleotide Protein
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