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rpoZ RNA polymerase subunit omega [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948160, updated on 26-Mar-2025
Official Symbol
rpoZ
Official Full Name
RNA polymerase subunit omega
Primary source
ECOCYC:EG10899
Locus tag
b3649
See related
ASAP:ABE-0011933
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3639; spoS
Summary
Stimulates ppGpp responsiveness of RNAP in vitro. [More information is available at EcoGene: EG10899]. RpoZ copurifies with RNA polymerase and may play a structural role in that complex. [More information is available at EcoCyc: EG10899].
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Sequence:
NC_000913.3 (3822106..3822381)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene PF03458 family inner membrane protein YicG Neighboring gene DNA ligase B Neighboring gene guanylate kinase Neighboring gene bifunctional (p)ppGpp synthase/hydrolase SpoT Neighboring gene tRNA (Gm18) 2'-O-methyltransferase

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A noncycling activity assay for the omega subunit of Escherichia coli RNA polymerase. Hansen UM, et al. J Biol Chem, 1979 Jul 10. PMID 376516
  2. Inter-subunit recognition and manifestation of segmental mobility in Escherichia coli RNA polymerase: a case study with omega-beta' interaction. Ghosh P, et al. Biophys Chem, 2003 Mar 25. PMID 12727285
  3. Conversion of the omega subunit of Escherichia coli RNA polymerase into a transcriptional activator or an activation target. Dove SL, et al. Genes Dev, 1998 Mar 1. PMID 9499408, Free PMC Article
  4. Studies on the omega subunit of Escherichia coli RNA polymerase--its role in the recovery of denatured enzyme activity. Mukherjee K, et al. Eur J Biochem, 1997 Aug 1. PMID 9288911
  5. Cross-linking of Escherichia coli RNA polymerase subunits: identification of beta' as the binding site of omega. Gentry DR, et al. Biochemistry, 1993 Oct 19. PMID 8218187

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study identified a new phenotype of rpoZ strain corresponding to defect in biofilm formation in minimal media.
    Title: The role of ω-subunit of Escherichia coli RNA polymerase in stress response.
  2. The results indicate that polyamine stimulation of synthesis of SpoT and RpoZ plays important roles for cell viability through stimulation of ppGpp synthesis by SpoT and modulation of RNA synthesis by ppGpp-RpoZ complex.
    Title: Increase in cell viability by polyamines through stimulation of the synthesis of ppGpp regulatory protein and ω protein of RNA polymerase in Escherichia coli.
  3. Deletion of rpoZ alters the sigma factor selectivity of promoter recognition.
    Title: Structural coupling between RNA polymerase composition and DNA supercoiling in coordinating transcription: a global role for the omega subunit?
  4. N-terminus verified by Edman degradation on mature peptide
    Title: Small genes/gene-products in Escherichia coli K-12.
  5. the omega subunit of RNA polymerase is involved in regulation of the relA gene
    Title: The role of the omega subunit of RNA polymerase in expression of the relA gene in Escherichia coli.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 5'-3' RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-directed RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
enables bacterial-type RNA polymerase core enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables bacterial-type RNA polymerase core enzyme binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA-templated transcription initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA-templated transcription initiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA-templated transcription initiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in bacterial-type flagellum assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in bacterial-type flagellum-dependent cell motility NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cell motility NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cellular response to cell envelope stress NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in intracellular iron ion homeostasis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in nitrate assimilation NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within protein-containing complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription elongation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of DNA-templated transcription initiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription initiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to heat NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in submerged biofilm formation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in transcription antitermination IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of DNA-directed RNA polymerase complex IEA
Inferred from Electronic Annotation
more info
  
part_of RNA polymerase complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic DNA-directed RNA polymerase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic DNA-directed RNA polymerase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of cytosolic DNA-directed RNA polymerase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
Preferred Names
RNA polymerase subunit omega

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3822106..3822381
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418106.1 RNA polymerase subunit omega [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418106.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9AXC3
    Conserved Domains (1) summary
    TIGR00690
    Location:1 → 60
    rpoZ; DNA-directed RNA polymerase, omega subunit
Nucleotide Protein
Heading Accession and Version

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