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waaP lipopolysaccharide core heptose (I) kinase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948150, updated on 17-Jul-2025
Official Symbol
waaP
Official Full Name
lipopolysaccharide core heptose (I) kinase
Primary source
ECOCYC:EG11340
Locus tag
b3630
See related
ASAP:ABE-0011866
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3620; rfaP
Summary
The lipopolysaccharide of Escherichia coli K-12 consists of two major components: the hydrophobic lipid A moiety inserted into the outer membrane and the phosphorylated core oligosaccharide . [More information is available at EcoCyc: EG11340].
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Sequence:
NC_000913.3 (3805153..3805950, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene UDP-D-glucose:(glucosyl)LPS alpha-1,3-glucosyltransferase Neighboring gene UDP-D-galactose:(glucosyl)lipopolysaccharide-1,6-D-galactosyltransferase Neighboring gene lipopolysaccharide core biosynthesis protein WaaS Neighboring gene lipopolysaccharide glucosyltransferase I Neighboring gene lipopolysaccharide core heptosyltransferase 3 Neighboring gene ncRNA

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Reduced lipopolysaccharide phosphorylation in Escherichia coli lowers the elevated ori/ter ratio in seqA mutants. Rotman E, et al. Mol Microbiol, 2009 Jun. PMID 19432803, Free PMC Article
  2. Mutation of the lipopolysaccharide core glycosyltransferase encoded by waaG destabilizes the outer membrane of Escherichia coli by interfering with core phosphorylation. Yethon JA, et al. J Bacteriol, 2000 Oct. PMID 10986272, Free PMC Article
  3. Identification of Tn10 insertions in the rfaG, rfaP, and galU genes involved in lipopolysaccharide core biosynthesis that affect Escherichia coli adhesion. Genevaux P, et al. Arch Microbiol, 1999 Jul. PMID 10398745
  4. Regulation of the OmpA outer membrane protein of Escherichia coli. Beher MG, et al. J Bacteriol, 1981 Sep. PMID 7024253, Free PMC Article
  5. Identification and sequences of the lipopolysaccharide core biosynthetic genes rfaQ, rfaP, and rfaG of Escherichia coli K-12. Parker CT, et al. J Bacteriol, 1992 Feb. PMID 1732225, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within lipopolysaccharide core region biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
lipopolysaccharide core heptose (I) kinase
NP_418087.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3805153..3805950 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418087.1 lipopolysaccharide core heptose (I) kinase

    See identical proteins and their annotated locations for NP_418087.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0AAN3Q3C1
    Conserved Domains (1) summary
    PRK15123
    Location:1 → 265
    PRK15123; lipopolysaccharide core heptose(I) kinase RfaP; Provisional
Nucleotide Protein
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