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waaP lipopolysaccharide core heptose (I) kinase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948150, updated on 6-May-2021

Summary

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Gene symbol
waaP
Gene description
lipopolysaccharide core heptose (I) kinase
Primary source
ASAP:ABE-0011866
Locus tag
b3630
See related
ECOCYC:EG11340
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3620; rfaP
Summary
The lipopolysaccharide of Escherichia coli K-12 consists of two major components: the hydrophobic lipid A moiety inserted into the outer membrane and the phosphorylated core oligosaccharide . [More information is available at EcoCyc: EG11340].
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Genomic context

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Sequence:
NC_000913.3 (3805153..3805950, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene UDP-D-glucose:(glucosyl)LPS alpha-1,3-glucosyltransferase Neighboring gene UDP-D-galactose:(glucosyl)lipopolysaccharide-1,6-D-galactosyltransferase Neighboring gene lipopolysaccharide core biosynthesis protein WaaS Neighboring gene lipopolysaccharide glucosyltransferase I Neighboring gene lipopolysaccharide core heptosyltransferase 3 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Purification and characterization of WaaP from Escherichia coli, a lipopolysaccharide kinase essential for outer membrane stability. Yethon JA, et al. J Biol Chem, 2001 Feb 23. PMID 11069912
  2. Reduced lipopolysaccharide phosphorylation in Escherichia coli lowers the elevated ori/ter ratio in seqA mutants. Rotman E, et al. Mol Microbiol, 2009 Jun. PMID 19432803, Free PMC Article
  3. Mutation of the lipopolysaccharide core glycosyltransferase encoded by waaG destabilizes the outer membrane of Escherichia coli by interfering with core phosphorylation. Yethon JA, et al. J Bacteriol, 2000 Oct. PMID 10986272, Free PMC Article
  4. Identification of Tn10 insertions in the rfaG, rfaP, and galU genes involved in lipopolysaccharide core biosynthesis that affect Escherichia coli adhesion. Genevaux P, et al. Arch Microbiol, 1999 Jul. PMID 10398745
  5. Involvement of waaY, waaQ, and waaP in the modification of Escherichia coli lipopolysaccharide and their role in the formation of a stable outer membrane. Yethon JA, et al. J Biol Chem, 1998 Oct 9. PMID 9756860

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Gene Ontology Provided by GO

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within lipopolysaccharide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipopolysaccharide core region biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within lipopolysaccharide core region biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lipopolysaccharide core heptose (I) kinase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3805153..3805950 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418087.1 lipopolysaccharide core heptose (I) kinase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418087.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P25741
    Conserved Domains (1) summary
    PRK15123
    Location:1 → 265
    PRK15123; lipopolysaccharide core heptose(I) kinase RfaP; Provisional
Nucleotide Protein
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Other Literature Sources
Molecular Biology Databases
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