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waaU putative ADP-heptose:LPS heptosyltransferase 4 [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948147, updated on 25-Jun-2025
Official Symbol
waaU
Official Full Name
putative ADP-heptose:LPS heptosyltransferase 4
Primary source
ECOCYC:EG11423
Locus tag
b3623
See related
ASAP:ABE-0011851
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3613; rfaK
Summary
The lipopolysaccharide of Escherichia coli K-12 consists of two major components: the hydrophobic lipid A moiety inserted into the outer membrane and the phosphorylated core oligosaccharide . [More information is available at EcoCyc: EG11423].
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Sequence:
NC_000913.3 (3798239..3799312, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene O-antigen ligase Neighboring gene protein YibX;protein YibX-S Neighboring gene protein YibY Neighboring gene lipopolysaccharide core biosynthesis protein WaaZ Neighboring gene lipopolysaccharide core heptose (II) kinase

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The assembly system for the lipopolysaccharide R2 core-type of Escherichia coli is a hybrid of those found in Escherichia coli K-12 and Salmonella enterica. Structure and function of the R2 WaaK and WaaL homologs. Heinrichs DE, et al. J Biol Chem, 1998 Apr 10. PMID 9535865
  2. Genetic analysis of the genes involved in synthesis of the lipopolysaccharide core in Escherichia coli K-12: three operons in the rfa locus. Roncero C, et al. J Bacteriol, 1992 May. PMID 1577693, Free PMC Article
  3. Role of the rfaG and rfaP genes in determining the lipopolysaccharide core structure and cell surface properties of Escherichia coli K-12. Parker CT, et al. J Bacteriol, 1992 Apr. PMID 1348243, Free PMC Article
  4. Role of Escherichia coli K-12 rfa genes and the rfp gene of Shigella dysenteriae 1 in generation of lipopolysaccharide core heterogeneity and attachment of O antigen. Klena JD, et al. J Bacteriol, 1992 Nov. PMID 1385388, Free PMC Article
  5. Physical maps of the rfa loci of Escherichia coli K-12 and Salmonella typhimurium. Schnaitman CA, et al. J Bacteriol, 1991 Dec. PMID 1938935, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ADP-heptose-lipopolysaccharide heptosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ADP-heptose-lipopolysaccharide heptosyltransferase activity RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
enables lipid A-core heptosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in lipopolysaccharide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipopolysaccharide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipopolysaccharide core region biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
putative ADP-heptose:LPS heptosyltransferase 4

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3798239..3799312 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418080.1 putative ADP-heptose:LPS heptosyltransferase 4 [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418080.1

    Status: PROVISIONAL

    Conserved Domains (1) summary
    COG0859
    Location:40 → 356
    RfaF; ADP-heptose:LPS heptosyltransferase [Cell wall/membrane/envelope biogenesis]
Nucleotide Protein
Heading Accession and Version

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