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waaU [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948147, updated on 11-Sep-2024

Summary

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Official Symbol
waaU
Primary source
ECOCYC:EG11423
Locus tag
b3623
See related
ASAP:ABE-0011851
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3613; rfaK
Summary
The lipopolysaccharide of Escherichia coli K-12 consists of two major components: the hydrophobic lipid A moiety inserted into the outer membrane and the phosphorylated core oligosaccharide . [More information is available at EcoCyc: EG11423].
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Genomic context

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Sequence:
NC_000913.3 (3798239..3799312, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene O-antigen ligase Neighboring gene protein YibX;protein YibX-S Neighboring gene protein YibY Neighboring gene lipopolysaccharide core biosynthesis protein WaaZ Neighboring gene lipopolysaccharide core heptose (II) kinase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The assembly system for the lipopolysaccharide R2 core-type of Escherichia coli is a hybrid of those found in Escherichia coli K-12 and Salmonella enterica. Structure and function of the R2 WaaK and WaaL homologs. Heinrichs DE, et al. J Biol Chem, 1998 Apr 10. PMID 9535865
  2. Genetic analysis of the genes involved in synthesis of the lipopolysaccharide core in Escherichia coli K-12: three operons in the rfa locus. Roncero C, et al. J Bacteriol, 1992 May. PMID 1577693, Free PMC Article
  3. Molecular basis for structural diversity in the core regions of the lipopolysaccharides of Escherichia coli and Salmonella enterica. Heinrichs DE, et al. Mol Microbiol, 1998 Oct. PMID 9791168
  4. Physical maps of the rfa loci of Escherichia coli K-12 and Salmonella typhimurium. Schnaitman CA, et al. J Bacteriol, 1991 Dec. PMID 1938935, Free PMC Article
  5. Role of Escherichia coli K-12 rfa genes and the rfp gene of Shigella dysenteriae 1 in generation of lipopolysaccharide core heterogeneity and attachment of O antigen. Klena JD, et al. J Bacteriol, 1992 Nov. PMID 1385388, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ADP-heptose-lipopolysaccharide heptosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ADP-heptose-lipopolysaccharide heptosyltransferase activity RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables lipid A-core heptosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables lipopolysaccharide N-acetylglucosaminyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in lipopolysaccharide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipopolysaccharide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipopolysaccharide core region biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipopolysaccharide core region biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
putative ADP-heptose:LPS heptosyltransferase 4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3798239..3799312 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418080.1 putative ADP-heptose:LPS heptosyltransferase 4 [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418080.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7VRG2
    Conserved Domains (1) summary
    COG0859
    Location:40 → 356
    RfaF; ADP-heptose:LPS heptosyltransferase [Cell wall/membrane/envelope biogenesis]
Nucleotide Protein
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