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cysE [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948126, updated on 11-Sep-2024

Summary

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Official Symbol
cysE
Primary source
ECOCYC:EG10187
Locus tag
b3607
See related
ASAP:ABE-0011793
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3597
Summary
CysE forms a bienzyme complex with CysK. [More information is available at EcoGene: EG10187]. Serine acetyltransferase carries out the first step in the pathway of cysteine biosynthesis, converting L-serine into O-acetyl-L-serine. [More information is available at EcoCyc: EG10187].
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Genomic context

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Sequence:
NC_000913.3 (3781741..3782562, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional dual regulator LldR Neighboring gene L-lactate dehydrogenase Neighboring gene tRNA (cytidine/uridine-2'-O)-ribose methyltransferase Neighboring gene glycerol-3-phosphate dehydrogenase Neighboring gene protein export chaperone SecB Neighboring gene reduced glutaredoxin 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Engineering of Escherichia coli L-serine O-acetyltransferase on the basis of crystal structure: desensitization to feedback inhibition by L-cysteine. Kai Y, et al. Protein Eng Des Sel, 2006 Apr. PMID 16459339
  2. On the interaction site of serine acetyltransferase in the cysteine synthase complex from Escherichia coli. Zhao C, et al. Biochem Biophys Res Commun, 2006 Mar 24. PMID 16442495
  3. Role of CysE in production of an extracellular signaling molecule in Providencia stuartii and Escherichia coli: loss of CysE enhances biofilm formation in Escherichia coli. Sturgill G, et al. J Bacteriol, 2004 Nov. PMID 15516574, Free PMC Article
  4. The structure and mechanism of serine acetyltransferase from Escherichia coli. Pye VE, et al. J Biol Chem, 2004 Sep 24. PMID 15231846
  5. Serine acetyltransferase of Escherichia coli: substrate specificity and feedback control by cysteine. Hindson VJ. Biochem J, 2003 Nov 1. PMID 12940772, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that bacterial serine acetyltransferase (CysE) is activated when bound to O-acetylserine sulfhydrylase-A sulfhydrylase (CysK).
    Title: Modulation of Escherichia coli serine acetyltransferase catalytic activity in the cysteine synthase complex.
  2. C-terminus of serine acetyltransferase, Ile 273, along with Glu 268 & Asp 271, was found to be essential for complex formation. Effects of O-acetyl-L-serine & sulfide on affinity for complex formation were also studied using surface plasmon technique.
    Title: On the interaction site of serine acetyltransferase in the cysteine synthase complex from Escherichia coli.
  3. required for the production of an extracellular signal molecule. CysE mutant formed biofilms at an accelerated rate compared to the wild type.
    Title: Role of CysE in production of an extracellular signaling molecule in Providencia stuartii and Escherichia coli: loss of CysE enhances biofilm formation in Escherichia coli.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables serine O-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine O-acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables serine O-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cysteine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cysteine biosynthetic process from serine IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cysteine biosynthetic process from serine IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cysteine biosynthetic process from serine IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to X-ray IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of cysteine synthase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cysteine synthase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
serine acetyltransferase
NP_418064.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3781741..3782562 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418064.1 serine acetyltransferase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418064.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5N8HKQ3
    Conserved Domains (1) summary
    PRK11132
    Location:1 → 273
    cysE; serine acetyltransferase; Provisional
Nucleotide Protein
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