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mtlA mannitol-specific PTS enzyme IICBA component [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948118, updated on 30-Jul-2025
Official Symbol
mtlA
Official Full Name
mannitol-specific PTS enzyme IICBA component
Primary source
ECOCYC:EG10615
Locus tag
b3599
See related
ASAP:ABE-0011761
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3588; mtlC
Summary
[More information is available at EcoCyc: EG10615].
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Sequence:
NC_000913.3 (3772281..3774194)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene inner membrane protein YibH Neighboring gene DUF3302 domain-containing protein YibI Neighboring gene mannitol-1-phosphate 5-dehydrogenase Neighboring gene transcriptional repressor MtlR Neighboring gene protein YibT

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. 1H, 13C, and 15N resonance assignments of the phosphorylated enzyme IIB of the mannitol-specific phosphoenolpyruvate-dependent phosphotransferase system of Escherichia coli. Otten R, et al. J Biomol NMR, 2004 Dec. PMID 15630568
  2. Mannitol-specific enzyme II of the bacterial phosphotransferase system. I. Properties of the purified permease. Jacobson GR, et al. J Biol Chem, 1983 Sep 10. PMID 6350293
  3. Plasmid-directed synthesis of enzymes required for D-mannitol transport and utilization in Escherichia coli. Lee CA, et al. Proc Natl Acad Sci U S A, 1981 Dec. PMID 6801648, Free PMC Article
  4. The intramembrane topography of the mannitol-specific enzyme II of the Escherichia coli phosphotransferase system. Jacobson GR, et al. J Biol Chem, 1983 Mar 10. PMID 6338009
  5. A fluorescence study of single tryptophan-containing mutants of enzyme IImtl of the Escherichia coli phosphoenolpyruvate-dependent mannitol transport system. Dijkstra DS, et al. Biochemistry, 1996 May 28. PMID 8639611

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-N(PI)-phosphohistidine-mannitol phosphotransferase system transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-N(PI)-phosphohistidine-sugar phosphotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-phosphocysteine-mannitol phosphotransferase system transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-phosphocysteine-sugar phosphotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within mannitol transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within mannitol transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphoenolpyruvate-dependent sugar phosphotransferase system IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphoenolpyruvate-dependent sugar phosphotransferase system IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphoenolpyruvate-dependent sugar phosphotransferase system IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphoenolpyruvate-dependent sugar phosphotransferase system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sorbitol transmembrane transport EXP
Inferred from Experiment
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
mannitol-specific PTS enzyme IICBA component
NP_418056.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3772281..3774194
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418056.1 mannitol-specific PTS enzyme IICBA component

    See identical proteins and their annotated locations for NP_418056.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A376M128, A0A8S7EAB5
    Conserved Domains (1) summary
    PRK15083
    Location:1 → 637
    PRK15083; PTS system mannitol-specific transporter subunit IICBA; Provisional
Nucleotide Protein
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