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lldP [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948114, updated on 24-Aug-2024

Summary

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Official Symbol
lldP
Primary source
ECOCYC:EG11961
Locus tag
b3603
See related
ASAP:ABE-0011777
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3593; lct; lctP
Summary
IT (Ion Transporter) superfamily (Prakash, 2003). [More information is available at EcoGene: EG11961]. LctP is a probable lactate/proton symporter responsible for the uptake of L-lactate. [More information is available at EcoCyc: EG11961].
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Genomic context

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Sequence:
NC_000913.3 (3777399..3779054)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein YibT Neighboring gene DUF2810 domain-containing protein YibL Neighboring gene DNA-binding transcriptional dual regulator LldR Neighboring gene L-lactate dehydrogenase Neighboring gene tRNA (cytidine/uridine-2'-O)-ribose methyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transport of L-Lactate, D-Lactate, and glycolate by the LldP and GlcA membrane carriers of Escherichia coli. Núñez MF, et al. Biochem Biophys Res Commun, 2002 Jan 18. PMID 11785976
  2. Cloning of a Neisseria meningitidis gene for L-lactate dehydrogenase (L-LDH): evidence for a second meningococcal L-LDH with different regulation. Erwin AL, et al. J Bacteriol, 1996 Aug. PMID 8759842, Free PMC Article
  3. Dual role of LldR in regulation of the lldPRD operon, involved in L-lactate metabolism in Escherichia coli. Aguilera L, et al. J Bacteriol, 2008 Apr. PMID 18263722, Free PMC Article
  4. Mapping the xyl, mtl, and lct loci in Escherichia coli K-12. Lin RJ, et al. J Bacteriol, 1983 Nov. PMID 6313625, Free PMC Article
  5. Vinylglycolate resistance in Escherichia coli. Shaw L, et al. J Bacteriol, 1975 Mar. PMID 1090585, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results are consistent with the hypothesis that LldR has a dual role, acting as a repressor or an activator of lldPRD operon.
    Title: Dual role of LldR in regulation of the lldPRD operon, involved in L-lactate metabolism in Escherichia coli.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables glycolate transmembrane transporter activity EXP
Inferred from Experiment
more info
 PubMed 
enables lactate transmembrane transporter activity EXP
Inferred from Experiment
more info
 PubMed 
enables lactate transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables solute:proton symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables solute:proton symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in glycolate transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lactate transmembrane transport EXP
Inferred from Experiment
more info
 PubMed 
involved_in lactate transport IEA
Inferred from Electronic Annotation
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 

General protein information

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Preferred Names
lactate/glycolate:H(+) symporter LldP

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3777399..3779054
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418060.1 lactate/glycolate:H(+) symporter LldP [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418060.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A7A6ZX80
    Conserved Domains (1) summary
    PRK10420
    Location:1 → 551
    PRK10420; L-lactate permease; Provisional
Nucleotide Protein
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