U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

aldB aldehyde dehydrogenase B [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948104, updated on 30-Jul-2025
Official Symbol
aldB
Official Full Name
aldehyde dehydrogenase B
Primary source
ECOCYC:EG12292
Locus tag
b3588
See related
ASAP:ABE-0011718
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3577; yiaX
Summary
AldB has NADP-dependent acetaldehyde dehydrogenase activity , which may be identical to the activity detected by Heim and Strehler in crude cell extracts . [More information is available at EcoCyc: EG12292].
Try the new Gene page
Try the new Transcripts and proteins table
Sequence:
NC_000913.3 (3754973..3756511, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional activator YiaU Neighboring gene putative membrane fusion protein YiaV Neighboring gene DUF3302 domain-containing protein YiaW Neighboring gene L-threonine dehydrogenase Neighboring gene selenocysteyl-tRNA-specific translation elongation factor Neighboring gene selenocysteine synthase

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. AldB controls persister formation in Escherichia coli depending on environmental stress. Kawai Y, et al. Microbiol Immunol, 2018 May. PMID 29577369
  2. aldB, an RpoS-dependent gene in Escherichia coli encoding an aldehyde dehydrogenase that is repressed by Fis and activated by Crp. Xu J, et al. J Bacteriol, 1995 Jun. PMID 7768815, Free PMC Article
  3. Transposon mutagenesis identifies genes which control antimicrobial drug tolerance in stationary-phase Escherichia coli. Hu Y, et al. FEMS Microbiol Lett, 2005 Feb 1. PMID 15668009
  4. Identification of genes negatively regulated by Fis: Fis and RpoS comodulate growth-phase-dependent gene expression in Escherichia coli. Xu J, et al. J Bacteriol, 1995 Feb. PMID 7860604, Free PMC Article
  5. Cloning an Escherichia coli gene encoding a protein remarkably similar to mammalian aldehyde dehydrogenases. Heim R, et al. Gene, 1991 Mar 1. PMID 1840553

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AldB controls persister formation in Escherichia coli depending on environmental stress.
    Title: AldB controls persister formation in Escherichia coli depending on environmental stress.
  2. N-terminus verified by Edman degradation on complete protein
    Title: Isolation and characterization of an aldehyde dehydrogenase encoded by the aldB gene of Escherichia coli.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables acetaldehyde dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
  
enables aldehyde dehydrogenase (NAD+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aldehyde dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
  
enables aldehyde dehydrogenase [NAD(P)+] activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to ethanol IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
aldehyde dehydrogenase B

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3754973..3756511 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418045.4 aldehyde dehydrogenase B

    See identical proteins and their annotated locations for NP_418045.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A376FUR7
    Conserved Domains (1) summary
    cd07559
    Location:25 → 504
    ALDH_ACDHII_AcoD-like; Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II and Staphylococcus aureus AldA1 (SACOL0154)-like
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.