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selB selenocysteyl-tRNA-specific translation elongation factor [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948103, updated on 4-Apr-2024

Summary

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Gene symbol
selB
Gene description
selenocysteyl-tRNA-specific translation elongation factor
Primary source
ASAP:ABE-0011729
Locus tag
b3590
See related
ECOCYC:EG10942
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3579; fdhA
Summary
SelB is a specialized translation factor that takes the place of elongation factor EF-Tu in the in the case of selenocysteine's being inserted into a peptide chain at the site of a UGA codon. [More information is available at EcoCyc: EG10942].
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Genomic context

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Sequence:
NC_000913.3 (3758017..3759861, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene aldehyde dehydrogenase B Neighboring gene L-threonine dehydrogenase Neighboring gene selenocysteine synthase Neighboring gene glutathione transferase-like protein YibF Neighboring gene rhs element protein RhsA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The involvement of SelB in the expression of cytotoxic necrotizing factor 1 in Escherichia coli. Yu H, et al. FEBS Lett, 2011 Jun 23. PMID 21570972
  2. Thermodynamic and kinetic framework of selenocysteyl-tRNASec recognition by elongation factor SelB. Paleskava A, et al. J Biol Chem, 2010 Jan 29. PMID 19940162, Free PMC Article
  3. Molecular switch in tandem winged-helix motifs of elongation factor SelB. Soler N, et al. Nucleic Acids Symp Ser (Oxf), 2007. PMID 18029744
  4. Crystallization and preliminary X-ray analysis of the mRNA-binding domain of elongation factor SelB from Escherichia coli in complex with RNA. Soler N, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2007 May 1. PMID 17565186, Free PMC Article
  5. Structural insight into a molecular switch in tandem winged-helix motifs from elongation factor SelB. Soler N, et al. J Mol Biol, 2007 Jul 20. PMID 17537456

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SelB is involved in translational regulation of cytotoxic necrotizing factor 1(CNF1) expression but without incorporation of selenocysteine in CNF1 protein.
    Title: The involvement of SelB in the expression of cytotoxic necrotizing factor 1 in Escherichia coli.
  2. analysis of the thermodynamic and kinetic framework of selenocysteyl-tRNASec recognition by elongation factor SelB
    Title: Thermodynamic and kinetic framework of selenocysteyl-tRNASec recognition by elongation factor SelB.
  3. N-terminus verified by Edman degradation on complete protein
    Title: Purification and biochemical characterization of SELB, a translation factor involved in selenoprotein synthesis.
  4. structures show that tandem winged-helix motifs not only provide an excellent scaffold for RNA binding but can also have an active role in the function of protein-RNA complexes
    Title: Structural insight into a molecular switch in tandem winged-helix motifs from elongation factor SelB.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables GDP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables anion binding IEA
Inferred from Electronic Annotation
more info
  
enables guanyl ribonucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables selenocysteine insertion sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables selenocysteine insertion sequence binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables tRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables translation elongation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in selenocysteine incorporation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in selenocysteine incorporation IEA
Inferred from Electronic Annotation
more info
  
involved_in selenocysteine incorporation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in selenocysteine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in selenocysteine metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
selenocysteyl-tRNA-specific translation elongation factor
NP_418047.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3758017..3759861 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418047.1 selenocysteyl-tRNA-specific translation elongation factor [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418047.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A418G9X2
    Conserved Domains (1) summary
    PRK10512
    Location:1 → 614
    PRK10512; selenocysteinyl-tRNA-specific translation factor; Provisional
Nucleotide Protein
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