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SLC25A27 solute carrier family 25 member 27 [ Homo sapiens (human) ]

Gene ID: 9481, updated on 11-Sep-2019

Summary

Official Symbol
SLC25A27provided by HGNC
Official Full Name
solute carrier family 25 member 27provided by HGNC
Primary source
HGNC:HGNC:21065
See related
Ensembl:ENSG00000153291 MIM:613725
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UCP4
Summary
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. Transcripts of this gene are only detected in brain tissue and are specifically modulated by various environmental conditions. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]
Expression
Broad expression in brain (RPKM 13.5), ovary (RPKM 8.8) and 22 other tissues See more
Orthologs

Genomic context

See SLC25A27 in Genome Data Viewer
Location:
6p12.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (46652915..46678190)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (46620652..46645927)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene regulator of calcineurin 2 Neighboring gene uncharacterized LOC101926898 Neighboring gene cytochrome P450 family 39 subfamily A member 1 Neighboring gene uncharacterized LOC101926934 Neighboring gene tudor domain containing 6 Neighboring gene phospholipase A2 group VII Neighboring gene ankyrin repeat domain 66

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of solute carrier family 25, member 27 (SLC25A27) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Electron Transport Chain, organism-specific biosystem (from WikiPathways)
    Electron Transport Chain, organism-specific biosystemAn electron transport chain(ETC) couples a chemical reaction between an electron donor (such as NADH) and an electron acceptor (such as O2) to the transfer of H+ ions across a membrane, through a set...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Mitochondrial Uncoupling Proteins, organism-specific biosystem (from REACTOME)
    Mitochondrial Uncoupling Proteins, organism-specific biosystemUncoupling proteins (UCPs) are members of the mitochondrial transport carrier family, and have been implicated in a wide range of physiological and pathological conditions. Physiological conditions i...
  • Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., organism-specific biosystem (from REACTOME)
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., organism-specific biosystemOxidation of fatty acids and pyruvate in the mitochondrial matrix yield large amounts of NADH. The respiratory electron transport chain couples the re-oxidation of this NADH to NAD+ to the export of ...
  • The citric acid (TCA) cycle and respiratory electron transport, organism-specific biosystem (from REACTOME)
    The citric acid (TCA) cycle and respiratory electron transport, organism-specific biosystemThe metabolism of pyruvate provides one source of acetyl-CoA which enters the citric acid (TCA, tricarboxylic acid) cycle to generate energy and the reducing equivalent NADH. These reducing equivalen...
  • The fatty acid cycling model, organism-specific biosystem (from REACTOME)
    The fatty acid cycling model, organism-specific biosystemThe "fatty acid cycling" hypothesis proposes that protonated fatty acids flip-flop in the membrane and deliver a proton to the matrix side. UCP1 catalyses the return of the fatty acid anion to the cy...
  • The proton buffering model, organism-specific biosystem (from REACTOME)
    The proton buffering model, organism-specific biosystemThe "proton buffering" model proposes that UCP1 is intrinsically a proton carrier, and that fatty acid acts as a prosthetic group during proton transport. Fatty acid penetrates from the lipid phase, ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ33552

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cellular triglyceride homeostasis IEA
Inferred from Electronic Annotation
more info
 
inner ear development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of mitochondrial calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
negative regulation of mitochondrial membrane potential IEA
Inferred from Electronic Annotation
more info
 
neuron death IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
proton transmembrane transport TAS
Traceable Author Statement
more info
 
regulation of glucose import IEA
Inferred from Electronic Annotation
more info
 
response to cold IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
apical part of cell IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
mitochondrial uncoupling protein 4
Names
UCP 4
uncoupling protein 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204051.2NP_001190980.1  mitochondrial uncoupling protein 4 isoform 2

    See identical proteins and their annotated locations for NP_001190980.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and lacks a portion of the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK295233, AL591242, BC033091, BP310559
    UniProtKB/Swiss-Prot
    O95847
    UniProtKB/TrEMBL
    B4DHR4
    Conserved Domains (2) summary
    PTZ00169
    Location:20299
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:123219
    Mito_carr; Mitochondrial carrier protein
  2. NM_001204052.1NP_001190981.1  mitochondrial uncoupling protein 4 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has multiple differences, compared to variant 1. These differences result in a distinct 3' UTR, compared to variant 1. The encoded protein (isoform 3) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL591242, BC033091, BP310559, DC314392, DR002070
    Consensus CDS
    CCDS56431.1
    UniProtKB/Swiss-Prot
    O95847
    Related
    ENSP00000412024.2, ENST00000411689.6
    Conserved Domains (1) summary
    pfam00153
    Location:123219
    Mito_carr; Mitochondrial carrier protein
  3. NM_004277.5NP_004268.3  mitochondrial uncoupling protein 4 isoform 1

    See identical proteins and their annotated locations for NP_004268.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AF110532, AL591242, DA144842
    Consensus CDS
    CCDS43470.1
    UniProtKB/Swiss-Prot
    O95847
    Related
    ENSP00000360398.3, ENST00000371347.10
    Conserved Domains (2) summary
    PTZ00169
    Location:20317
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:123219
    Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    46652915..46678190
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005249483.2XP_005249540.1  mitochondrial uncoupling protein 4 isoform X1

    Conserved Domains (2) summary
    PTZ00169
    Location:20299
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:123219
    Mito_carr; Mitochondrial carrier protein
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