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glyQ glycine--tRNA ligase subunit alpha [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948079, updated on 30-Jul-2025
Official Symbol
glyQ
Official Full Name
glycine--tRNA ligase subunit alpha
Primary source
ECOCYC:EG10409
Locus tag
b3560
See related
ASAP:ABE-0011626
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
cfcA; ECK3548; glyS(A)
Summary
Glycyl-tRNA synthetase (GlyRS) is a member of the family of aminoacyl-tRNA synthetases, which interpret the genetic code by covalently linking amino acids to their specific tRNA molecules. [More information is available at EcoCyc: EG10409].
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Sequence:
NC_000913.3 (3724407..3725318, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene glycine--tRNA ligase Neighboring gene putative lipoprotein YsaB Neighboring gene O-acetyltransferase WecH

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A mutation in the small (alpha) subunit of glycyl-tRNA synthetase affects amino acid activation and subunit association parameters. Toth MJ, et al. J Biol Chem, 1990 Jan 15. PMID 2295596
  2. Rapid determination of nucleotides that define tRNA(Gly) acceptor identity. McClain WH, et al. Proc Natl Acad Sci U S A, 1991 Jul 15. PMID 2068095, Free PMC Article
  3. Internal structural features of E. coli glycyl-tRNA synthetase examined by subunit polypeptide chain fusions. Toth MJ, et al. J Biol Chem, 1986 May 25. PMID 3009467
  4. Glycyl-tRNA synthetase: an oligomeric protein containing dissimilar subunits. Ostrem DL, et al. Proc Natl Acad Sci U S A, 1970 Dec. PMID 4923123, Free PMC Article
  5. Gene for Escherichia coli glycyl-tRNA synthetase has tandem subunit coding regions in the same reading frame. Keng T, et al. J Biol Chem, 1982 Nov 10. PMID 6290471

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to glycine-tRNA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glycine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in glycyl-tRNA aminoacylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glycyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of glycine-tRNA ligase complex EXP
Inferred from Experiment
more info
 PubMed 
part_of glycine-tRNA ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of glycine-tRNA ligase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
Preferred Names
glycine--tRNA ligase subunit alpha
NP_418017.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3724407..3725318 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418017.1 glycine--tRNA ligase subunit alpha

    See identical proteins and their annotated locations for NP_418017.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8S7EAE3
    Conserved Domains (1) summary
    PRK09348
    Location:5 → 292
    glyQ; glycyl-tRNA synthetase subunit alpha; Validated
Nucleotide Protein
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