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ghrB [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948074, updated on 11-Sep-2024

Summary

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Official Symbol
ghrB
Primary source
ECOCYC:EG12272
Locus tag
b3553
See related
ASAP:ABE-0011604
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3540; tkrA; yiaE
Summary
AFMB Structural Genomics target Number 33 (http://afmb.cnrs-mrs.fr/article171.html). [More information is available at EcoGene: EG12272].
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Genomic context

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Sequence:
NC_000913.3 (3717310..3718284)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene peptidyl-lysine N-acetyltransferase YiaC Neighboring gene biotin sulfoxide reductase Neighboring gene PF13488 family lipoprotein YiaD Neighboring gene DUF3053 domain-containing protein YiaF Neighboring gene putative DNA-binding transcriptional regulator YiaG

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The yiaE gene, located at 80.1 minutes on the Escherichia coli chromosome, encodes a 2-ketoaldonate reductase. Yum DY, et al. J Bacteriol, 1998 Nov. PMID 9811658, Free PMC Article
  2. Biochemical characterization of the 2-ketoacid reductases encoded by ycdW and yiaE genes in Escherichia coli. Nuñez MF, et al. Biochem J, 2001 Mar 15. PMID 11237876, Free PMC Article
  3. Identification of the yqhE and yafB genes encoding two 2, 5-diketo-D-gluconate reductases in Escherichia coli. Yum DY, et al. Appl Environ Microbiol, 1999 Aug. PMID 10427017, Free PMC Article
  4. From the genome sequence to the proteome and back: evaluation of E. coli genome annotation with a 2-D gel-based proteomics approach. Maillet I, et al. Proteomics, 2007 Apr. PMID 17366475
  5. Proteome analysis of Escherichia coli using high-performance liquid chromatography and Fourier transform ion cyclotron resonance mass spectrometry. Ihling C, et al. Proteomics, 2005 May. PMID 15852340

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: Escherichia coli YrbI is 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables gluconate 2-dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables gluconate 2-dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables glyoxylate reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glyoxylate reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glyoxylate reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
  
enables hydroxypyruvate reductase (NADH) activity IEA
Inferred from Electronic Annotation
more info
  
enables hydroxypyruvate reductase [NAD(P)H] activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydroxypyruvate reductase [NAD(P)H] activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in D-gluconate metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ketogluconate catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glyoxylate reductase
NP_418009.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3717310..3718284
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418009.2 glyoxylate reductase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418009.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2X1N5B3
    Conserved Domains (1) summary
    PRK15409
    Location:1 → 323
    PRK15409; glyoxylate/hydroxypyruvate reductase GhrB
Nucleotide Protein
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