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eptB phosphoethanolamine transferase EptB [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948068, updated on 25-Jun-2025
Official Symbol
eptB
Official Full Name
phosphoethanolamine transferase EptB
Primary source
ECOCYC:EG12267
Locus tag
b3546
See related
ASAP:ABE-0011581
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3533; yhjW
Summary
Localized to the inner membrane by subcellular fractionation (Reynolds, 2005). [More information is available at EcoGene: EG12267]. The eptB gene encodes the Ca2+-induced phosphoethanolamine transferase . [More information is available at EcoCyc: EG12267].
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Sequence:
NC_000913.3 (3708784..3710475, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene dipeptide ABC transporter periplasmic binding protein Neighboring gene tRNA-Pro Neighboring gene putative transporter YhjX Neighboring gene putative outer membrane protein YhjY

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Ca2+-induced phosphoethanolamine transfer to the outer 3-deoxy-D-manno-octulosonic acid moiety of Escherichia coli lipopolysaccharide. A novel membrane enzyme dependent upon phosphatidylethanolamine. Kanipes MI, et al. J Biol Chem, 2001 Jan 12. PMID 11042192
  2. Deletion of the heptosyltransferase genes rfaC and rfaF in Escherichia coli K-12 results in an Re-type lipopolysaccharide with a high degree of 2-aminoethanol phosphate substitution. Brabetz W, et al. Eur J Biochem, 1997 Jul 15. PMID 9266718
  3. Phosphoethanolamine substitution in the lipid A of Escherichia coli O157 : H7 and its association with PmrC. Kim SH, et al. Microbiology (Reading), 2006 Mar. PMID 16514146
  4. A pmrA constitutive mutant sensitizes Escherichia coli to deoxycholic acid. Froelich JM, et al. J Bacteriol, 2006 Feb. PMID 16428424, Free PMC Article
  5. A PhoQ/P-regulated small RNA regulates sensitivity of Escherichia coli to antimicrobial peptides. Moon K, et al. Mol Microbiol, 2009 Dec. PMID 19889087, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the active site of EptB faces the periplasmic surface of the inner membrane
    Title: A phosphoethanolamine transferase specific for the outer 3-deoxy-D-manno-octulosonic acid residue of Escherichia coli lipopolysaccharide. Identification of the eptB gene and Ca2+ hypersensitivity of an eptB deletion mutant.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables phosphatidylethanolamine:Kdo2-lipid A phosphoethanolamine transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylethanolamine:Kdo2-lipid A phosphoethanolamine transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in lipid A biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lipid A biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lipopolysaccharide core region biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
phosphoethanolamine transferase EptB
NP_418002.2

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3708784..3710475 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418002.2 phosphoethanolamine transferase EptB [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418002.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7SKV1
    Conserved Domains (1) summary
    PRK11560
    Location:1 → 558
    PRK11560; kdo(2)-lipid A phosphoethanolamine 7''-transferase
Nucleotide Protein
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Gene LinkOut

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