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mdtF [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948030, updated on 24-Aug-2024

Summary

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Official Symbol
mdtF
Primary source
ASAP:ABE-0011480
Locus tag
b3514
See related
ECOCYC:EG12241
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3498; yhiV
Summary
EvgAS regulon. [More information is available at EcoGene: EG12241]. MdtF is a component of the MdtEF multidrug transporter. [More information is available at EcoCyc: EG12241].
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Genomic context

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Sequence:
NC_000913.3 (3660414..3663527)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene multidrug efflux pump membrane fusion protein MdtE Neighboring gene DNA-binding transcriptional dual regulator GadW Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Altered spectrum of multidrug resistance associated with a single point mutation in the Escherichia coli RND-type MDR efflux pump YhiV (MdtF). Bohnert JA, et al. J Antimicrob Chemother, 2007 Jun. PMID 17062614
  2. Extreme Acid Modulates Fitness Trade-Offs of Multidrug Efflux Pumps MdtEF-TolC and AcrAB-TolC in Escherichia coli K-12. Schaffner SH, et al. Appl Environ Microbiol, 2021 Jul 27. PMID 34085861, Free PMC Article
  3. Role of the AraC-XylS family regulator YdeO in multi-drug resistance of Escherichia coli. Nishino K, et al. J Antibiot (Tokyo), 2009 May. PMID 19329985
  4. Roles of TolC-dependent multidrug transporters of Escherichia coli in resistance to beta-lactams. Nishino K, et al. Antimicrob Agents Chemother, 2003 Sep. PMID 12937021, Free PMC Article
  5. CRP regulator modulates multidrug resistance of Escherichia coli by repressing the mdtEF multidrug efflux genes. Nishino K, et al. J Antibiot (Tokyo), 2008 Mar. PMID 18503189

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Extreme Acid Modulates Fitness Trade-Offs of Multidrug Efflux Pumps MdtEF-TolC and AcrAB-TolC in Escherichia coli K-12.
    Title: Extreme Acid Modulates Fitness Trade-Offs of Multidrug Efflux Pumps MdtEF-TolC and AcrAB-TolC in Escherichia coli K-12.
  2. GadX increases multidrug resistance in E. coli through activation of the MdtEF efflux pump.
    Title: The AraC-family regulator GadX enhances multidrug resistance in Escherichia coli by activating expression of mdtEF multidrug efflux genes.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables bile acid transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables efflux transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables xenobiotic transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables xenobiotic transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within bile acid and bile salt transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to antibiotic IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to antibiotic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to toxic substance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within xenobiotic transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in xenobiotic transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within xenobiotic transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
multidrug efflux pump RND permease MdtF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3660414..3663527
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417971.1 multidrug efflux pump RND permease MdtF [Escherichia coli str. K-12 substr. MG1655]

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376FUZ1, A0A793GLF9, A0A8S7I1T5
    Conserved Domains (1) summary
    PRK15127
    Location:1 → 1018
    PRK15127; multidrug efflux RND transporter permease subunit AcrB
Nucleotide Protein
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