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arsC arsenate reductase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948018, updated on 30-Jul-2025
Official Symbol
arsC
Official Full Name
arsenate reductase
Primary source
ECOCYC:EG12237
Locus tag
b3503
See related
ASAP:ABE-0011439
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
arsG; ECK3488
Summary
ArsC reduces arsenate to arsenite so it can be extruded through ArsB. [More information is available at EcoGene: EG12237]. Based on sequence similarity with the R773-plasmid encoded arsenite resistance operon, ArsB is a transporter and ArsC is an arsenate reductase . [More information is available at EcoCyc: EG12237].
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Sequence:
NC_000913.3 (3650237..3650662)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional repressor ArsR Neighboring gene arsenite/antimonite:H(+) antiporter Neighboring gene pseudo Neighboring gene IS5 transposase and trans-activator Neighboring gene starvation lipoprotein

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Arginine 60 in the ArsC arsenate reductase of E. coli plasmid R773 determines the chemical nature of the bound As(III) product. DeMel S, et al. Protein Sci, 2004 Sep. PMID 15295115, Free PMC Article
  2. Ligand interactions of the ArsC arsenate reductase. Liu J, et al. J Biol Chem, 1997 Aug 22. PMID 9261111
  3. Reactivity of glutaredoxins 1, 2, and 3 from Escherichia coli shows that glutaredoxin 2 is the primary hydrogen donor to ArsC-catalyzed arsenate reduction. Shi J, et al. J Biol Chem, 1999 Dec 17. PMID 10593884
  4. The ars operon of Escherichia coli confers arsenical and antimonial resistance. Carlin A, et al. J Bacteriol, 1995 Feb. PMID 7860609, Free PMC Article
  5. Transport pathways for arsenic and selenium: a minireview. Rosen BP, et al. Environ Int, 2009 Apr. PMID 18789529, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables arsenate reductase (glutaredoxin) activity IEA
Inferred from Electronic Annotation
more info
  
enables arsenate reductase (glutaredoxin) activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to arsenic-containing substance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to arsenic-containing substance IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to arsenic-containing substance IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to arsenic-containing substance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Preferred Names
arsenate reductase
NP_417960.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3650237..3650662
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417960.1 arsenate reductase

    See identical proteins and their annotated locations for NP_417960.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8S7K204
    Conserved Domains (1) summary
    PRK10026
    Location:1 → 141
    PRK10026; arsenate reductase (glutaredoxin)
Nucleotide Protein
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