U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

hycB hydrogenase 3 [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948002, updated on 4-Feb-2026
Official Symbol
hycB
Official Full Name
hydrogenase 3
Primary source
ECOCYC:EG10475
Locus tag
b2724
See related
ASAP:ABE-0008950
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2719; hevB
Summary
FhlA regulon. [More information is available at EcoGene: EG10475]. HycB is thought to code for a subunit of hydrogenase 3, a peptide of the [4Fe-4S] ferredoxin type, which functions as an intermediate electron carrier protein between hydrogenase 3 and formate dehydrogenase . [More information is available at EcoCyc: EG10475].
Try the new Gene page
Try the new Transcripts and proteins table
Sequence:
NC_000913.3 (2849238..2849849, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene hydrogenase 3 large subunit Neighboring gene hydrogenase 3 membrane subunit HycD Neighboring gene hydrogenase 3 membrane subunit HycC Neighboring gene regulator of the transcriptional regulator FhlA Neighboring gene hydrogenase 3 Ni(2(+)) incorporation protein HypA

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Mechanism of regulation of the formate-hydrogenlyase pathway by oxygen, nitrate, and pH: definition of the formate regulon. Rossmann R, et al. Mol Microbiol, 1991 Nov. PMID 1779767
  2. Microbial reduction of technetium by Escherichia coli and Desulfovibrio desulfuricans: enhancement via the use of high-activity strains and effect of process parameters. Lloyd JR, et al. Biotechnol Bioeng, 1999. PMID 10567070
  3. Reduction and removal of heptavalent technetium from solution by Escherichia coli. Lloyd JR, et al. J Bacteriol, 1997 Mar. PMID 9068649, Free PMC Article
  4. [K+-dependent enzyme activity of H+-ATPase in the E. coli membrane]. Trchunian AA, et al. Biofizika, 1991 Jan-Feb. PMID 1830224
  5. Relationship between formate hydrogen lyase and proton-potassium pump under heterolactic fermentation in Escherichia coli: functional multienzyme associations in the cell membrane. Trchounian AA, et al. Membr Cell Biol, 2000. PMID 10926369

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables 4 iron, 4 sulfur cluster binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in anaerobic electron transport chain IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in anaerobic respiration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in formate oxidation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glucose catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
hydrogenase 3
NP_417204.1

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2849238..2849849 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417204.1 hydrogenase 3 [Fe-S] protein HycB

    See identical proteins and their annotated locations for NP_417204.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A376D3R9, A0A376MGR1
    Conserved Domains (1) summary
    cd10554
    Location:4 → 167
    HycB_like; HycB, HydN and similar proteins
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.