Format

Send to:

Choose Destination

ONECUT2 one cut homeobox 2 [ Homo sapiens (human) ]

Gene ID: 9480, updated on 1-Jun-2020

Summary

Official Symbol
ONECUT2provided by HGNC
Official Full Name
one cut homeobox 2provided by HGNC
Primary source
HGNC:HGNC:8139
See related
Ensembl:ENSG00000119547 MIM:604894
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OC2; OC-2
Summary
This gene encodes a member of the onecut family of transcription factors, which are characterized by a cut domain and an atypical homeodomain. The protein binds to specific DNA sequences and stimulates expression of target genes, including genes involved in melanocyte and hepatocyte differentiation. [provided by RefSeq, Jul 2008]
Expression
Biased expression in gall bladder (RPKM 4.8), duodenum (RPKM 3.7) and 2 other tissues See more
Orthologs

Genomic context

See ONECUT2 in Genome Data Viewer
Location:
18q21.31
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (57435374..57491298)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (55102917..55158530)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 737, pseudogene Neighboring gene ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 Neighboring gene uncharacterized LOC112267870 Neighboring gene FOXA motif-containing MPRA enhancer 78 Neighboring gene ferrochelatase Neighboring gene asparaginyl-tRNA synthetase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC120377, MGC120378

Gene Ontology Provided by GOA

Process Evidence Code Pubs
animal organ morphogenesis TAS
Traceable Author Statement
more info
PubMed 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell fate commitment IEA
Inferred from Electronic Annotation
more info
 
cilium assembly IEA
Inferred from Electronic Annotation
more info
 
endocrine pancreas development IEA
Inferred from Electronic Annotation
more info
 
epithelial cell development IEA
Inferred from Electronic Annotation
more info
 
liver development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
peripheral nervous system neuron development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
actin cytoskeleton IDA
Inferred from Direct Assay
more info
 
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
one cut domain family member 2
Names
HNF-6-beta
ONECUT-2 homeodomain transcription factor
hepatocyte nuclear factor 6-beta
onecut 2
transcription factor ONECUT-2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004852.3NP_004843.2  one cut domain family member 2

    See identical proteins and their annotated locations for NP_004843.2

    Status: REVIEWED

    Source sequence(s)
    AC090340, BC013134, Y18198
    Consensus CDS
    CCDS42440.1
    UniProtKB/Swiss-Prot
    O95948
    Related
    ENSP00000419185.2, ENST00000491143.3
    Conserved Domains (2) summary
    smart00389
    Location:426481
    HOX; Homeodomain
    pfam02376
    Location:331403
    CUT; CUT domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    57435374..57491298
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center