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yhiM inner membrane protein YhiM [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947997, updated on 19-Nov-2025
Official Symbol
yhiM
Official Full Name
inner membrane protein YhiM
Primary source
ECOCYC:EG12228
Locus tag
b3491
See related
ASAP:ABE-0011400
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3476
Summary
EvgAS regulon. [More information is available at EcoGene: EG12228]. YhiM is an inner membrane protein with ten predicted membrane spanning domains; its C terminus is located in the cytoplasm . [More information is available at EcoCyc: EG12228].
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Sequence:
NC_000913.3 (3634841..3635893)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF4049 domain-containing protein YhiJ Neighboring gene pseudo Neighboring gene putative oxidoreductase YhiN Neighboring gene metal phosphate:H(+) symporter PitA

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The inner membrane protein YhiM is necessary for Escherichia coli growth at high temperatures and low osmolarity. Anderson MA, et al. Arch Microbiol, 2017 Jan. PMID 27629277
  2. The inner membrane protein, YhiM, is necessary for Escherichia coli (E. coli) survival in acidic conditions. Nguyen TM, et al. Arch Microbiol, 2012 Jul. PMID 22327802
  3. Anticipating an alkaline stress through the Tor phosphorelay system in Escherichia coli. Bordi C, et al. Mol Microbiol, 2003 Apr. PMID 12657056
  4. Gene expression profiling of the pH response in Escherichia coli. Tucker DL, et al. J Bacteriol, 2002 Dec. PMID 12426343, Free PMC Article
  5. Low temperature (23 degrees C) increases expression of biofilm-, cold-shock- and RpoS-dependent genes in Escherichia coli K-12. White-Ziegler CA, et al. Microbiology (Reading), 2008 Jan. PMID 18174134

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. YhiM is important in protecting the cells from changes in temperature and osmolarity.
    Title: The inner membrane protein YhiM is necessary for Escherichia coli growth at high temperatures and low osmolarity.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by EcoCyc

Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to acidic pH IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within cellular response to acidic pH IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in temperature homeostasis IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 
Preferred Names
inner membrane protein YhiM

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3634841..3635893
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417948.4 inner membrane protein YhiM

    See identical proteins and their annotated locations for NP_417948.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A7L7EDW5, A0AAN3TS92
    Conserved Domains (1) summary
    pfam10951
    Location:1 → 348
    DUF2776; Protein of unknown function (DUF2776)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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