U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

nikE [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947987, updated on 11-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
nikE
Primary source
ECOCYC:EG12079
Locus tag
b3480
See related
ASAP:ABE-0011362
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3464; hydC; hydD
Summary
Mutants display nickel-remediated formate hydrogen-lyase, hydrogenase, and hydrogenase-related fumarase defects. [More information is available at EcoGene: EG12079]. The NikABCDE ATP-dependent nickel (II) uptake system is a member of the ATP-Binding Cassette (ABC) Superfamily of transporters . [More information is available at EcoCyc: EG12079].
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000913.3 (3617776..3618582)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene Ni(2(+)) ABC transporter periplasmic binding protein Neighboring gene Ni(2(+)) ABC transporter membrane subunit NikB Neighboring gene Ni(2(+)) ABC transporter membrane subunit NikC Neighboring gene Ni(2(+)) ABC transporter ATP binding subunit NikD Neighboring gene DNA-binding transcriptional repressor NikR Neighboring gene rhs element protein RhsB Neighboring gene PF15631 family protein YhhH

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Genetic and physiological characterization of new Escherichia coli mutants impaired in hydrogenase activity. Wu LF, et al. Biochimie, 1986 Jan. PMID 3089308
  2. Identification of Ni-(L-His)₂ as a substrate for NikABCDE-dependent nickel uptake in Escherichia coli. Chivers PT, et al. Metallomics, 2012 Oct. PMID 22885853
  3. Crystallographic and spectroscopic evidence for high affinity binding of FeEDTA(H2O)- to the periplasmic nickel transporter NikA. Cherrier MV, et al. J Am Chem Soc, 2005 Jul 20. PMID 16011372
  4. Purification and characterization of the periplasmic nickel-binding protein NikA of Escherichia coli K12. de Pina K, et al. Eur J Biochem, 1995 Feb 1. PMID 7867647
  5. The hydC region contains a multi-cistronic operon (nik) involved in nickel transport in Escherichia coli. Wu LF, et al. Gene, 1991 Oct 30. PMID 1743519

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ABC-type nickel transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding ISM
Inferred from Sequence Model
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables nickel cation binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in nickel cation import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nickel cation import across plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in nickel cation transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing NAS
Non-traceable Author Statement
more info
 PubMed 
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Ni(2(+)) ABC transporter ATP binding subunit NikE

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3617776..3618582
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417937.1 Ni(2(+)) ABC transporter ATP binding subunit NikE [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417937.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376FST8
    Conserved Domains (1) summary
    PRK10419
    Location:1 → 268
    nikE; nickel ABC transporter ATP-binding protein NikE
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.