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zntA Zn(2(+))/Cd(2(+))/Pb(2(+)) exporting P-type ATPase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947972, updated on 9-Mar-2022

Summary

Gene symbol
zntA
Gene description
Zn(2(+))/Cd(2(+))/Pb(2(+)) exporting P-type ATPase
Primary source
ECOCYC:EG12215
Locus tag
b3469
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3453; yhhO
Summary
HAD superfamily. [More information is available at EcoGene: EG12215]. The gene product of the yhhO gene, also referred to as zntA, is a P-type ATPase involved in the efflux of Pb(II), Cd(II), and Zn(II) . [More information is available at EcoCyc: EG12215].
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Genomic context

Sequence:
NC_000913.3 (3606451..3608649)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF2500 domain-containing protein YhhM Neighboring gene PF07947 family protein YhhN Neighboring gene sulfur transfer protein TusA Neighboring gene queuosine precursor transporter

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity ISA
Inferred from Sequence Alignment
more info
PubMed 
enables ATPase-coupled cation transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables P-type cadmium transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables P-type zinc transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables P-type zinc transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables cadmium ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables lead ion transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cadmium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cadmium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cation transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within detoxification of zinc ion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ion transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lead ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within metal ion transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within nickel cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to cadmium ion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to lead ion IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within response to zinc ion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within zinc ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within zinc ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within zinc ion transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within zinc ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of plasma membrane ISM
Inferred from Sequence Model
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Zn(2(+))/Cd(2(+))/Pb(2(+)) exporting P-type ATPase
NP_417926.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3606451..3608649
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417926.1 Zn(2(+))/Cd(2(+))/Pb(2(+)) exporting P-type ATPase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417926.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P37617
    Conserved Domains (1) summary
    NF033775
    Location:1732
    P_type_ZntA; Zn(II)/Cd(II)/Pb(II) translocating P-type ATPase ZntA