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livJ branched chain amino acid/phenylalanine ABC transporter periplasmic binding protein [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947971, updated on 6-Jul-2026
Official Symbol
livJ
Official Full Name
branched chain amino acid/phenylalanine ABC transporter periplasmic binding protein
Primary source
ECOCYC:EG10539
Locus tag
b3460
See related
ASAP:ABE-0011299
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3444; hrbB; hrbC; hrbD
Summary
After four hours of Zn(II) stress, LivJ protein levels decreased (Easton, 2006). [More information is available at EcoGene: EG10539]. LivFGHMJ and LivFGHMK are two ATP-dependent high-affinity branched-chain amino acid transport system and are members of the ATP Binding Cassette (ABC) Superfamily of transporters . [More information is available at EcoCyc: EG10539].
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Sequence:
NC_000913.3 (3598555..3599658, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene L-leucine/L-phenylalanine ABC transporter periplasmic binding protein Neighboring gene PanD maturation factor Neighboring gene RNA polymerase sigma factor RpoH Neighboring gene cell division protein FtsX Neighboring gene cell division protein FtsE

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. (19)F NMR studies of the leucine-isoleucine-valine binding protein: evidence that a closed conformation exists in solution. Salopek-Sondi B, et al. J Biomol Struct Dyn, 2003 Oct. PMID 12956607
  2. Crystal structure of AmiC: the controller of transcription antitermination in the amidase operon of Pseudomonas aeruginosa. Pearl L, et al. EMBO J, 1994 Dec 15. PMID 7813419, Free PMC Article
  3. A portion of the nucleotide sequence corresponding to the N-terminal coding region of livJ is essential for its transcriptional regulation. Matsubara K, et al. Biochim Biophys Acta, 2000 Nov 15. PMID 11072068
  4. Ligand-free and -bound structures of the binding protein (LivJ) of the Escherichia coli ABC leucine/isoleucine/valine transport system: trajectory and dynamics of the interdomain rotation and ligand specificity. Trakhanov S, et al. Biochemistry, 2005 May 3. PMID 15850393
  5. Premature termination of in vivo transcription of a gene encoding a branched-chain amino acid transport protein in Escherichia coli. Williamson RM, et al. J Bacteriol, 1992 Mar. PMID 1372312, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: The gcvB gene encodes a small untranslated RNA involved in expression of the dipeptide and oligopeptide transport systems in Escherichia coli.
  2. Two different ligand-free structures of LivJ, combined with those of the very similar ligand-bound forms, indicate the trajectory and backbone torsion angle changes of the hinges that accompany domain closure and play crucial functional roles.
    Title: Ligand-free and -bound structures of the binding protein (LivJ) of the Escherichia coli ABC leucine/isoleucine/valine transport system: trajectory and dynamics of the interdomain rotation and ligand specificity.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Process Evidence Code Pubs
involved_in L-leucine transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-leucine transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within L-leucine transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within branched-chain amino acid transport EXP
Inferred from Experiment
more info
 PubMed 
involved_in branched-chain amino acid transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in isoleucine transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within isoleucine transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in valine transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within valine transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing NAS
Non-traceable Author Statement
more info
 PubMed 
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in outer membrane-bounded periplasmic space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in outer membrane-bounded periplasmic space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in outer membrane-bounded periplasmic space IEA
Inferred from Electronic Annotation
more info
  
located_in outer membrane-bounded periplasmic space ISM
Inferred from Sequence Model
more info
 PubMed 
located_in periplasmic space IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
branched chain amino acid/phenylalanine ABC transporter periplasmic binding protein
YP_026223.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3598555..3599658 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_026223.1 branched chain amino acid/phenylalanine ABC transporter periplasmic binding protein

    See identical proteins and their annotated locations for YP_026223.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0H2Z414
    Conserved Domains (1) summary
    PRK15404
    Location:1 → 367
    PRK15404; high-affinity branched-chain amino acid ABC transporter substrate-binding protein
Nucleotide Protein
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