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livK L-leucine/L-phenylalanine ABC transporter periplasmic binding protein [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947964, updated on 17-Dec-2024
Official Symbol
livK
Official Full Name
L-leucine/L-phenylalanine ABC transporter periplasmic binding protein
Primary source
ECOCYC:EG10540
Locus tag
b3458
See related
ASAP:ABE-0011292
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3442; hrbB; hrbC; hrbD
Summary
The crystal structure of LivK in both the apo- and ligand-bound form has been determined at 1.5 and 1.8 A resolution . [More information is available at EcoCyc: EG10540].
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Sequence:
NC_000913.3 (3596451..3597560, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene branched chain amino acid/phenylalanine ABC transporter ATP binding subunit LivG Neighboring gene branched chain amino acid/phenylalanine ABC transporter membrane subunit LivM Neighboring gene branched chain amino acid/phenylalanine ABC transporter membrane subunit LivH Neighboring gene PanD maturation factor Neighboring gene branched chain amino acid/phenylalanine ABC transporter periplasmic binding protein

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Amino-terminal sequence and processing of the precursor of the leucine-specific binding protein, and evidence for conformational differences between the precursor and the mature form. Oxender DL, et al. Proc Natl Acad Sci U S A, 1980 Apr. PMID 6990419, Free PMC Article
  2. Structure of the L-leucine-binding protein refined at 2.4 A resolution and comparison with the Leu/Ile/Val-binding protein structure. Sack JS, et al. J Mol Biol, 1989 Mar 5. PMID 2649683
  3. 19F NMR study of the leucine-specific binding protein of Escherichia coli: mutagenesis and assignment of the 5-fluorotryptophan-labeled residues. Salopek-Sondi B, et al. Protein Eng, 2002 Nov. PMID 12538904
  4. Exploring the role of amino acid-18 of the leucine binding proteins of E. coli. Salopek-Sondi B, et al. J Biomol Struct Dyn, 2002 Dec. PMID 12437376
  5. Sequence and structural similarities between the leucine-specific binding protein and leucyl-tRNA synthetase of Escherichia coli. Williamson RM, et al. Proc Natl Acad Sci U S A, 1990 Jun. PMID 2191293, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables L-leucine binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within L-leucine transport EXP
Inferred from Experiment
more info
 PubMed 
involved_in L-leucine transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within L-leucine transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in branched-chain amino acid transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in isoleucine transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phenylalanine transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in valine transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing NAS
Non-traceable Author Statement
more info
 PubMed 
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in outer membrane-bounded periplasmic space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in outer membrane-bounded periplasmic space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in periplasmic space IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
L-leucine/L-phenylalanine ABC transporter periplasmic binding protein
NP_417915.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3596451..3597560 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417915.1 L-leucine/L-phenylalanine ABC transporter periplasmic binding protein [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417915.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6N8R8H6
    Conserved Domains (1) summary
    PRK15404
    Location:1 → 369
    PRK15404; high-affinity branched-chain amino acid ABC transporter substrate-binding protein
Nucleotide Protein
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